DegronMD - Q9NQW8(CNGB3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E736Q	TCGA-33-4532	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6744
p.E736Q	DO26626	LUSC	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6744
p.G734V	TCGA-36-2545	OV	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6421
p.G734V	DO28015	OV	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6421
p.P746Q	TCGA-37-4135	LUSC	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1111
p.P746Q	DO229028	LICA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1111
p.P746Q	DO26806	LUSC	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1111
p.E704G	TCGA-56-A4ZK	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.7199
p.E704G	DO45496	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.7199
p.E729Q	TCGA-78-7156	LUAD	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.E729Q	TCGA-GV-A3QF	BLCA	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.E729Q	DO471	BLCA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.E729Q	DO23720	LUAD	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.R696G	TCGA-79-5596	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1667
p.R696G	DO27357	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1667
p.D739Y	TCGA-AA-A010	COAD	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.3056
p.E704D	TCGA-AX-A0J0	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6758
p.E704D	DO221118	MALY	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6758
p.E704D	DO41133	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6758
p.K742N	TCGA-BP-4993	KIRC	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation substituting flanking lysine	0.3333
p.K742N	DO20171	KIRC	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation substituting flanking lysine	0.3333
p.G713R	TCGA-CV-7568	HNSC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1389
p.G713R	DO14160	HNSC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1389
p.E738K	TCGA-D3-A8GQ	SKCM	TCGA	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.591
p.E738K	DO51246	SKCM	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.591
p.K695N	TCGA-DF-A2KU	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation substituting flanking lysine	0.25
p.K695N	DO223286	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation substituting flanking lysine	0.25
p.S706A	TCGA-EO-A22X	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6477
p.S706A	DO43907	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6477
p.E707K	TCGA-EW-A1PD	BRCA	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.3056
p.E707K	DO4921	BRCA	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.3056
p.E711K	TCGA-FS-A1ZK	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.E711K	DO37474	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.E697D	TCGA-HU-A4H8	STAD	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.E697D	DO47869	STAD	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1944
p.E715Q	TCGA-Q1-A5R1	CESC	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0833
p.E715Q	DO44352	CESC	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0833
p.E715K	TCGA-WE-A8K5	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0833
p.E715K	DO51282	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.0833
p.E704Q	DO1088	BRCA	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation altering degron motif	0.6744
p.Q727E	DO14232	HNSC	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	DO231221	THCA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	SIDM00807	Bladder Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	ACH-000483	Liver Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	ACH-001484	Leukemia	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	SNU-182	liver	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727E	5637	urinary tract	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	DO14232	HNSC	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	DO231221	THCA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	SIDM01151	Hepatocellular Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	SIDM00807	Bladder Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	ACH-000483	Liver Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	ACH-001484	Leukemia	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	SNU-182	liver	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.Q727R	5637	urinary tract	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1389
p.D741G	DO231987	LICA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.25
p.G743E	DO220878	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.G743E	DO222578	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.1944
p.E731K	DO220877	MELA	ICGC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.25
p.K714T	DO222731	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation substituting flanking lysine	0.2222
p.E712D	DO228011	SKCA	ICGC	KKENS	DEG_APCC_KENBOX_2	702:706	Mutation rewiring degron network	0.1667
p.E748Q	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.0556
p.E748Q	ACH-000861	Lung Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.0556
p.E748Q	HOP-62	lung	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation rewiring degron network	0.0556
p.G734R	SIDM01147	Gastric Carcinoma	GDSC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6457
p.G734R	ACH-000427	Gastric Cancer	CCLE	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6457
p.G734R	NCI-N87	stomach	COSMIC	GKENE	DEG_APCC_KENBOX_2	734:738	Mutation altering degron motif	0.6457

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNGB3

UniProt ID: Q9NQW8

Entrez ID: 54714

Protein name: Cyclic nucleotide-gated cation channel beta-3 (Cone photoreceptor cGMP-gated channel subunit beta) (Cyclic nucleotide-gated cation channel modulatory subunit) (Cyclic nucleotide-gated channel beta-3) (CNG channel beta-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNGB3 in