DegronMD

Uniprot ID: Q9NQW8

Source protein: Cyclic nucleotide-gated cation channel beta-3

Source gene: CNGB3

Class: DEG_APCC_KENBOX_2

Location: 702:706

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5372

ASA_SCORE: 129.92

COIL: 0.5282

CONS_SCORE: 0.5085

DSS_SCORE: 0.6631

HELIX: 0.4682

FCONS_SCORE: 1.0147

RIG_SCORE: 0.5885

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E704G	TCGA-56-A4ZK	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.7199
p.E704G	DO45496	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7199
p.R696G	TCGA-79-5596	LUSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1667
p.R696G	DO27357	LUSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.E704D	TCGA-AX-A0J0	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6758
p.E704D	DO221118	MALY	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6758
p.E704D	DO41133	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6758
p.G713R	TCGA-CV-7568	HNSC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1389
p.G713R	DO14160	HNSC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1389
p.K695N	TCGA-DF-A2KU	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.25
p.K695N	DO223286	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.25
p.S706A	TCGA-EO-A22X	UCEC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.6477
p.S706A	DO43907	UCEC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6477
p.E707K	TCGA-EW-A1PD	BRCA	TCGA	KKENS	DEG_APCC_KENBOX_2	0.3056
p.E707K	DO4921	BRCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.3056
p.E711K	TCGA-FS-A1ZK	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1944
p.E711K	DO37474	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.E697D	TCGA-HU-A4H8	STAD	TCGA	KKENS	DEG_APCC_KENBOX_2	0.1944
p.E697D	DO47869	STAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1944
p.E715Q	TCGA-Q1-A5R1	CESC	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0833
p.E715Q	DO44352	CESC	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0833
p.E715K	TCGA-WE-A8K5	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	0.0833
p.E715K	DO51282	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0833
p.E704Q	DO1088	BRCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.6744
p.K714T	DO222731	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2222
p.E712D	DO228011	SKCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons