DegronMD - Q9BY89(KIAA1671)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K131M	DO8634	COAD	ICGC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.25
p.K131M	DO8634	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1111
p.H617Y	DO224721	COCA	ICGC	FQTVWATV	DEG_MDM2_SWIB_1	607:614	Mutation rewiring degron network	0.25
p.K667Q	DO222798	COCA	ICGC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.2778
p.P125L	DO222715	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation altering degron motif	0.7582
p.P1262L	DO233207	GACA	ICGC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.1111
p.M1425I	DO228948	LICA	ICGC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation altering degron motif	0.6507
p.G659C	DO228952	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.0556
p.G1421C	DO228976	LICA	ICGC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation altering degron motif	0.6489
p.G455V	DO229034	LICA	ICGC	ISLFRE	LIG_APCC_ABBA_1	441:446	Mutation rewiring degron network	0.0833
p.G119C	DO229034	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1944
p.K439R	DO229047	LICA	ICGC	ISLFRE	LIG_APCC_ABBA_1	441:446	Mutation rewiring degron network	0.2778
p.G123D	DO50970	LICA	ICGC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.3056
p.R153Q	DO231010	LUSC	ICGC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.R153Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.S673F	DO228398	PRAD	ICGC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation altering degron motif	0.7982
p.D134N	DO218850	SKCA	ICGC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.1667
p.D134N	DO218850	SKCA	ICGC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1944
p.G153S	SIDM01951	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.0556
p.D661N	SIDM01090	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	SIDM00200	Ewing's Sarcoma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	SIDM00875	Breast Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	SIDM00032	Bladder Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	SIDM00720	Mesothelioma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	SCaBER	urinary tract	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	NCI-H28	pleura	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	EW-12	bone	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	RKO	large intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.D661N	HCC1806	breast	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1111
p.V599I	SIDM00855	Other Sarcomas	GDSC	FQTVWATV	DEG_MDM2_SWIB_1	607:614	Mutation rewiring degron network	0.1111
p.V599I	G-402	soft tissue	COSMIC	FQTVWATV	DEG_MDM2_SWIB_1	607:614	Mutation rewiring degron network	0.1111
p.I1058V	SIDM00993	Plasma Cell Myeloma	GDSC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation altering degron motif	0.5965
p.I1058V	AMO-1	haematopoietic and lymphoid tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation altering degron motif	0.5965
p.G1257R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.25
p.G1257R	GR-ST	haematopoietic and lymphoid tissue	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.25
p.S1066F	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation rewiring degron network	0.25
p.S1066F	TE-11	oesophagus	COSMIC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation rewiring degron network	0.25
p.E122K	SIDM00122	Breast Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.2778
p.G1242R	SIDM00690	Head and Neck Carcinoma	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.2222
p.G1242R	SIDM00309	Mesothelioma	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.2222
p.G1242R	JHU-029	upper aerodigestive tract	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.2222
p.G1242R	H2803	pleura	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	1246:1254	Mutation rewiring degron network	0.2222
p.A1428T	SIDM01099	Neuroblastoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.A1428T	SIDM00882	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.A1428T	SIDM01187	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.A1428D	SIDM01099	Neuroblastoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.A1428D	SIDM00882	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.A1428D	SIDM01187	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	1418:1426	Mutation rewiring degron network	0.2778
p.P679S	SIDM00003	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1667
p.P679S	M14	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	669:673	Mutation rewiring degron network	0.1667
p.R445Q	SIDM00936	Bladder Carcinoma	GDSC	ISLFRE	LIG_APCC_ABBA_1	441:446	Mutation altering degron motif	0.6218
p.R445Q	CAL-29	urinary tract	COSMIC	ISLFRE	LIG_APCC_ABBA_1	441:446	Mutation altering degron motif	0.6218
p.L146F	SIDM00929	Chondrosarcoma	GDSC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.L146F	CAL-78	bone	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.25
p.N132K	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.2222
p.N132K	SIDM00921	Non-Small Cell Lung Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.N132K	Calu-6	lung	COSMIC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation rewiring degron network	0.2222
p.N132K	Calu-6	lung	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation rewiring degron network	0.1389
p.R1056K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation rewiring degron network	0.2778
p.R1056K	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation rewiring degron network	0.2778
p.I1058N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation altering degron motif	0.728
p.I1058N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	1058:1063	Mutation altering degron motif	0.728
p.G120S	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	PRTSS	DEG_SPOP_SBC_1	124:128	Mutation blocking phosphorylation signal	0.6667
p.S142N	OCI-LY7	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7069
p.S142N	RC-K8	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7069
p.S142N	GCT	soft tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7069
p.S142N	MLMA	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation altering degron motif	0.7069
p.Q151H	SNU-1040	large intestine	COSMIC	PSSST	DEG_SPOP_SBC_1	139:143	Mutation substituting flanking lysine	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIAA1671

UniProt ID: Q9BY89

Entrez ID: 85379

Protein name: Uncharacterized protein KIAA1671

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KIAA1671 in