DegronMD

Uniprot ID: Q9BY89

Source protein: Uncharacterized protein KIAA1671

Source gene: KIAA1671

Class: DEG_APCC_DBOX_1

Location: 1246:1254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 99.9889

COIL: 0.6272

CONS_SCORE: 0.4689

DSS_SCORE: 0.6282

HELIX: 0.3371

FCONS_SCORE: 1.4366

RIG_SCORE: 0.7082

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1262L	DO233207	GACA	ICGC	RRRSLKEMP	DEG_APCC_DBOX_1	0.1111
p.G1257R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	0.25
p.G1257R	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	0.25
p.G1242R	SIDM00690	Head and Neck Carcinoma	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	0.2222
p.G1242R	SIDM00309	Mesothelioma	GDSC	RRRSLKEMP	DEG_APCC_DBOX_1	0.2222
p.G1242R	JHU-029	upper_aerodigestive_tract	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	0.2222
p.G1242R	H2803	pleura	COSMIC	RRRSLKEMP	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_DBOX_1	1246:1254	RRRSLKEMP	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons