DegronMD

Uniprot ID: Q9BY89

Source protein: Uncharacterized protein KIAA1671

Source gene: KIAA1671

Class: DEG_APCC_DBOX_1

Location: 1418:1426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6012

ASA_SCORE: 93.8667

COIL: 0.7058

CONS_SCORE: 0.5141

DSS_SCORE: 0.6106

HELIX: 0.2532

FCONS_SCORE: 0.9527

RIG_SCORE: 0.7002

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1425I	DO228948	LICA	ICGC	IREGLSIMH	DEG_APCC_DBOX_1	0.6507
p.G1421C	DO228976	LICA	ICGC	IREGLSIMH	DEG_APCC_DBOX_1	0.6489
p.A1428T	SIDM01099	Neuroblastoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778
p.A1428T	SIDM00882	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778
p.A1428T	SIDM01187	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778
p.A1428D	SIDM01099	Neuroblastoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778
p.A1428D	SIDM00882	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778
p.A1428D	SIDM01187	Breast Carcinoma	GDSC	IREGLSIMH	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_DBOX_1	1418:1426	IREGLSIMH	APC,CDC20,FZR1	0.6012	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons