DegronMD

Uniprot ID: Q9BY89

Source protein: Uncharacterized protein KIAA1671

Source gene: KIAA1671

Class: DEG_SCF_FBW7_1

Location: 1058:1063

E3 ligase: FBXW7

DEGRON score: 0.9894

ASA_SCORE: 91.2

COIL: 0.9735

CONS_SCORE: 0.454

DSS_SCORE: 0.5648

HELIX: 0.0107

FCONS_SCORE: 1.2661

RIG_SCORE: 0.5805

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1058V	SIDM00993	Plasma Cell Myeloma	GDSC	ITPPSS	DEG_SCF_FBW7_1	0.5965
p.I1058V	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	0.5965
p.S1066F	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	ITPPSS	DEG_SCF_FBW7_1	0.25
p.S1066F	TE-11	oesophagus	COSMIC	ITPPSS	DEG_SCF_FBW7_1	0.25
p.R1056K	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.R1056K	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.I1058N	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ITPPSS	DEG_SCF_FBW7_1	0.728
p.I1058N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ITPPSS	DEG_SCF_FBW7_1	0.728

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_FBW7_1	331:336	ITPPSS	FBXW7	0.9558	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SCF_FBW7_1	1058:1063	ITPPSS	FBXW7	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons