DegronMD - Q16799(RTN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P146H	TCGA-05-4382	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.7694
p.P146H	DO24900	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.7694
p.T286M	TCGA-06-5408	GBM	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0556
p.T286M	TCGA-06-5408	GBM	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.T286M	TCGA-AA-3492	COAD	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0556
p.T286M	TCGA-AA-3492	COAD	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.T286M	DO8224	COAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0556
p.T286M	DO8224	COAD	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.T286M	DO12862	GBM	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0556
p.T286M	DO12862	GBM	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.D326N	TCGA-06-5416	GBM	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.1944
p.D326N	DO10880	GBM	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.1944
p.D184V	TCGA-06-A5U1	GBM	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.D184V	DO50111	GBM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.G144C	TCGA-17-Z053	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6489
p.D266N	TCGA-18-3409	LUSC	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.D266N	DO26444	LUSC	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.D266N	SIDM00663	Melanoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.D266N	ACH-000814	Skin Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.D266N	Hs939-T	skin	COSMIC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.3056
p.M170I	TCGA-19-5955	GBM	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.6507
p.M170I	TCGA-19-5955	GBM	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.6507
p.M170I	DO12208	GBM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.6507
p.M170I	DO12208	GBM	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.6507
p.T176K	TCGA-22-5479	LUSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.3056
p.T176K	TCGA-22-5479	LUSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.T176K	DO27287	LUSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.3056
p.T176K	DO27287	LUSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.T296N	TCGA-23-1118	OV	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5944
p.T296N	TCGA-23-1118	OV	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7055
p.T296N	DO30220	OV	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5944
p.T296N	DO30220	OV	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7055
p.Q304E	TCGA-37-A5EM	LUSC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.3056
p.Q304E	TCGA-37-A5EM	LUSC	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.Q304E	DO223719	LUSC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.3056
p.Q304E	DO223719	LUSC	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.E256K	TCGA-3N-A9WD	SKCM	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2222
p.E256K	DO51235	SKCM	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2222
p.S268F	TCGA-43-6647	LUSC	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.25
p.S268F	DO26514	LUSC	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.25
p.G160C	TCGA-49-6743	LUAD	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.1111
p.G160C	TCGA-49-6743	LUAD	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.G160C	DO26092	LUAD	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.1111
p.G160C	DO26092	LUAD	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.G329V	TCGA-50-5930	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G329V	DO25189	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G147V	TCGA-55-7994	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6421
p.G147V	DO45311	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6421
p.P340R	TCGA-86-7713	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2222
p.P340R	DO24712	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2222
p.P340T	TCGA-86-7713	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2222
p.P340T	DO24712	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2222
p.P148S	TCGA-91-6836	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5641
p.P148S	DO23854	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5641
p.S311T	TCGA-AA-3663	COAD	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1111
p.S311T	DO9346	COAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1111
p.E141K	TCGA-AC-A23H	BRCA	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2778
p.E141K	DO2401	BRCA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2778
p.E256Q	TCGA-AG-A020	READ	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2222
p.E256Q	DO36451	READ	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2222
p.P290H	TCGA-AP-A051	UCEC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1667
p.P290H	TCGA-AP-A051	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.2778
p.P290H	DO42673	UCEC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1667
p.P290H	DO42673	UCEC	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.2778
p.L308I	TCGA-AP-A1DV	UCEC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1944
p.L308I	DO43186	UCEC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1944
p.P323S	TCGA-AX-A0J1	UCEC	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.1111
p.P323S	DO41199	UCEC	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.1111
p.S164Y	TCGA-BA-A6DA	HNSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2222
p.S164Y	TCGA-BA-A6DA	HNSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.3056
p.S164Y	DO44448	HNSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2222
p.S164Y	DO44448	HNSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.3056
p.E339G	TCGA-BC-A216	LIHC	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.25
p.E339G	DO22929	LIHC	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.25
p.I264T	TCGA-C5-A1ME	CESC	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.5966
p.I264T	DO49878	CESC	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.5966
p.S258F	TCGA-CG-5721	STAD	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2778
p.S258F	DO38192	STAD	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.2778
p.F260L	TCGA-CK-4951	COAD	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.587
p.F260L	DO10582	COAD	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.587
p.T171A	TCGA-CV-7407	HNSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7139
p.T171A	TCGA-CV-7407	HNSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.7139
p.T171A	DO15711	HNSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7139
p.T171A	DO15711	HNSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.7139
p.E339K	TCGA-D3-A8GL	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.25
p.E339K	DO50287	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.25
p.S345F	TCGA-DA-A1HW	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.0833
p.S345F	DO229387	BTCA	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.0833
p.S345F	DO38129	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.0833
p.E142K	TCGA-DA-A95X	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.3056
p.E142K	DO219480	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.3056
p.D152Y	TCGA-DK-A6AW	BLCA	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.25
p.D152Y	DO48566	BLCA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.25
p.G337E	TCGA-EE-A2MS	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.3056
p.G337E	DO37567	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.3056
p.E322K	TCGA-EE-A2MS	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.0833
p.E322K	DO37567	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.0833
p.E289Q	TCGA-EK-A2RB	CESC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1389
p.E289Q	TCGA-EK-A2RB	CESC	TCGA	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.25
p.E289Q	DO48989	CESC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1389
p.E289Q	DO48989	CESC	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.25
p.E302K	TCGA-EK-A2RK	CESC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.591
p.E302K	DO49952	CESC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.591
p.I156V	TCGA-EO-A3KX	UCEC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1389
p.I156V	TCGA-EO-A3KX	UCEC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.0833
p.I156V	DO219774	UCEC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1389
p.I156V	DO219774	UCEC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.0833
p.R273K	TCGA-IB-7651	PAAD	TCGA	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1111
p.R273K	DO46657	PAAD	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1111
p.A173E	TCGA-J2-8194	LUAD	TCGA	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.659
p.A173E	DO23971	LUAD	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.659
p.G329E	TCGA-VS-A959	CESC	TCGA	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G329E	DO51640	CESC	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G329E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G329E	ACH-000916	Lung Cancer	CCLE	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.G329E	NCI-H1573	lung	COSMIC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation rewiring degron network	0.2778
p.S137L	TCGA-YG-AA3N	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1667
p.S137L	DO51298	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1667
p.E298Q	DO218173	BRCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.6744
p.P312H	DO227980	COCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0833
p.E298G	DO234363	ESAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7199
p.R272C	DO233736	GACA	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272C	SIDM00783	Colorectal Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272C	ACH-000971	Colon/Colorectal Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.K299N	DO228941	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM00615	Hepatocellular Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM00611	Kidney Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM00498	Colorectal Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM00616	Hepatocellular Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.K299N	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.5806
p.T294N	DO228974	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7055
p.P148T	DO229018	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5919
p.P148T	DO229041	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5919
p.P148T	ACH-000775	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5919
p.P148T	NCI-H727	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.5919
p.P310T	DO229019	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1389
p.P153T	DO229022	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2222
p.T332N	DO229026	LICA	ICGC	ITPPSS	DEG_SCF_FBW7_1	331:336	Mutation altering degron motif	0.7055
p.Q271K	DO229038	LICA	ICGC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1667
p.T286K	DO229038	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0556
p.T286K	DO229038	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1667
p.T172N	DO229037	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7055
p.A183D	DO229045	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.1111
p.L169I	DO229006	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7174
p.L169I	DO229006	LICA	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.7174
p.D184Y	DO50754	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.D184Y	SIDM01582	Gastric Carcinoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.D184Y	ACH-000507	Gastric Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.I306T	DO50954	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.25
p.I306T	DO50954	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.0556
p.K184T	DO45083	LINC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.0833
p.L308V	DO231078	LUSC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.1944
p.P153S	DO26560	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2222
p.P153S	DO51407	PRAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2222
p.V154E	DO45462	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1944
p.G133S	DO52023	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.0556
p.S291F	DO220875	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation blocking phosphorylation signal	0.6389
p.S291F	DO220875	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation blocking phosphorylation signal	0.75
p.E174K	DO220877	MELA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.591
p.E287K	DO222653	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0833
p.E287K	DO222653	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1944
p.E287D	DO222875	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.0833
p.E287D	DO222875	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1944
p.C307F	DO232016	ORCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation rewiring degron network	0.2222
p.E177K	DO218280	ORCA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.E177K	DO218280	ORCA	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1667
p.E177K	SIDM00962	Chronic Myelogenous Leukemia	GDSC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.E177K	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1667
p.E177K	SIDM01679	Small Cell Lung Carcinoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2778
p.E177K	SIDM01679	Small Cell Lung Carcinoma	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1667
p.H173N	DO37896	SKCM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7423
p.T151I	DO50119	STAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.2778
p.A134T	DO38727	STAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.0833
p.T284P	SIDM02059	Colorectal Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1111
p.R272H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM00773	Non-Cancerous	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM00845	Burkitt's Lymphoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM00493	Other Solid Cancers	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.R272H	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.E169D	SIDM00291	Melanoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.5647
p.E169D	SIDM00291	Melanoma	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.5647
p.E169D	ACH-002040	Skin Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.5647
p.E169D	ACH-002040	Skin Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.5647
p.E169D	HMV-II	skin	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.5647
p.E169D	HMV-II	skin	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.5647
p.P148H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6583
p.P148H	ACH-000860	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6583
p.P148H	NCI-H358	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6583
p.K303N	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.6918
p.K303N	ACH-000893	Lung Cancer	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.6918
p.K303N	NCI-H1651	lung	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.6918
p.G147C	SIDM00507	Other Solid Cancers	GDSC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6489
p.G147C	ACH-001490	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6489
p.G147C	COR-L321	NS	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.6489
p.T176M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.3056
p.T176M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.T176M	ACH-000922	Leukemia	CCLE	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.3056
p.T176M	ACH-000922	Leukemia	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.T176M	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.3056
p.T176M	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1944
p.Y263C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.7087
p.Y263C	ACH-000823	Esophageal Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.7087
p.Y263C	KYSE-140	oesophagus	COSMIC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.7087
p.L285P	SIDM01060	Melanoma	GDSC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1389
p.L285P	ACH-000882	Skin Cancer	CCLE	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1389
p.L285P	IGR-1	skin	COSMIC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1389
p.H253Y	SIDM00596	Endometrial Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.H253Y	ACH-001517	Endometrial/Uterine Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.H253Y	HEC-1	endometrium	COSMIC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1389
p.T145A	SIDM00871	Non-Cancerous	GDSC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.825
p.T145A	SIDM00872	Breast Carcinoma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation altering degron motif	0.825
p.P301T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7031
p.P301T	ACH-000945	Lung Cancer	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7031
p.P301T	NCI-H650	lung	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7031
p.E270K	SIDM00488	Colorectal Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.E270K	SIDM00169	Head and Neck Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.E270K	SIDM01588	Endometrial Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.E270K	SIDM01442	Glioma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.A261T	SIDM00045	Gastric Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.6028
p.A261T	ACH-002141	Gastric Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.6028
p.A261T	HSC-39	stomach	COSMIC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation altering degron motif	0.6028
p.T140I	ACH-000694	Esophageal Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.25
p.T140I	TE-9	oesophagus	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.25
p.V155L	ACH-000830	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1667
p.V155L	ACH-000830	Lung Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.0556
p.V155L	NCI-H1436	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1667
p.V155L	NCI-H1436	lung	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.0556
p.V178E	ACH-000979	Prostate Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.25
p.V178E	ACH-000979	Prostate Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1389
p.V178E	DU-145	prostate	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.25
p.V178E	DU-145	prostate	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1389
p.E298K	ACH-001982	Metastasis	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7022
p.A285T	MN-60	haematopoietic and lymphoid tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation rewiring degron network	0.1389
p.S293L	LC-2-ad	lung	COSMIC	VETTT	DEG_SPOP_SBC_1	292:296	Mutation altering degron motif	0.7667
p.V170L	NCI-H1436	lung	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.6765
p.V170L	NCI-H1436	lung	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.6765
p.H179Y	HEC-1	endometrium	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation rewiring degron network	0.2222
p.H179Y	HEC-1	endometrium	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.1111
p.A297T	OACM5-1	oesophagus	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	296:303	Mutation altering degron motif	0.7139
p.D166G	SNU-1040	large intestine	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.7198
p.G255E	NCI-H1573	lung	COSMIC	FAPYID	LIG_APCC_ABBA_1	260:265	Mutation rewiring degron network	0.1944
p.G173V	BV-173	haematopoietic and lymphoid tissue	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.7532
p.A169V	SNU-81	large intestine	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	168:175	Mutation altering degron motif	0.6936
p.A169V	SNU-81	large intestine	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation altering degron motif	0.6936
p.T155I	TE-9	oesophagus	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	143:149	Mutation rewiring degron network	0.1667
p.T155I	TE-9	oesophagus	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	165:171	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RTN1

UniProt ID: Q16799

Entrez ID: 6252

Protein name: Reticulon-1 (Neuroendocrine-specific protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RTN1 in