DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SCF_FBW7_1

Location: 168:175

E3 ligase: FBXW7

DEGRON score: 0.9876

ASA_SCORE: 81.6875

COIL: 0.763

CONS_SCORE: 0.4087

DSS_SCORE: 0.5316

HELIX: 0.0796

FCONS_SCORE: 1.1051

RIG_SCORE: 0.6933

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D184V	TCGA-06-A5U1	GBM	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.D184V	DO50111	GBM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.M170I	TCGA-19-5955	GBM	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.6507
p.M170I	DO12208	GBM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.6507
p.T176K	TCGA-22-5479	LUSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.3056
p.T176K	DO27287	LUSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.3056
p.G160C	TCGA-49-6743	LUAD	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.1111
p.G160C	DO26092	LUAD	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.1111
p.S164Y	TCGA-BA-A6DA	HNSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.2222
p.S164Y	DO44448	HNSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.2222
p.T171A	TCGA-CV-7407	HNSC	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.7139
p.T171A	DO15711	HNSC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.7139
p.A173E	TCGA-J2-8194	LUAD	TCGA	IEMTPAES	DEG_SCF_FBW7_1	0.659
p.A173E	DO23971	LUAD	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.659
p.T172N	DO229037	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.7055
p.A183D	DO229045	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.1111
p.L169I	DO229006	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.7174
p.D184Y	DO50754	LICA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.D184Y	SIDM01582	Gastric Carcinoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.D184Y	ACH-000507	Gastric Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.K184T	DO45083	LINC	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.0833
p.E174K	DO220877	MELA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.591
p.E177K	DO218280	ORCA	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.2778
p.E177K	SIDM00962	Chronic Myelogenous Leukemia	GDSC	IEMTPAES	DEG_SCF_FBW7_1	0.2778
p.E177K	SIDM01679	Small Cell Lung Carcinoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	0.2778
p.H173N	DO37896	SKCM	ICGC	IEMTPAES	DEG_SCF_FBW7_1	0.7423
p.E169D	SIDM00291	Melanoma	GDSC	IEMTPAES	DEG_SCF_FBW7_1	0.5647
p.E169D	ACH-002040	Skin Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	0.5647
p.E169D	HMV-II	skin	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.5647
p.T176M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	IEMTPAES	DEG_SCF_FBW7_1	0.3056
p.T176M	ACH-000922	Leukemia	CCLE	IEMTPAES	DEG_SCF_FBW7_1	0.3056
p.T176M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.3056
p.V178E	ACH-000979	Prostate Cancer	CCLE	IEMTPAES	DEG_SCF_FBW7_1	0.25
p.V178E	DU-145	prostate	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.25
p.V170L	NCI-H1436	lung	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.6765
p.H179Y	HEC-1	endometrium	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.2222
p.G173V	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.7532
p.A169V	SNU-81	large_intestine	COSMIC	IEMTPAES	DEG_SCF_FBW7_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IEMTPAES

Degron related mutations and impact score

Drug responses associated with RTN1 mutations

All proteins holding degron of IEMTPAES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_FBW7_1	168:175	IEMTPAES	FBXW7	0.9876	More...