DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SCF_TRCP1_1

Location: 165:171

E3 ligase: BTRC

DEGRON score: 0.9956

ASA_SCORE: 79.9429

COIL: 0.789

CONS_SCORE: 0.4234

DSS_SCORE: 0.5749

HELIX: 0.0354

FCONS_SCORE: 1.1782

RIG_SCORE: 0.6605

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M170I	TCGA-19-5955	GBM	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.6507
p.M170I	DO12208	GBM	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.6507
p.T176K	TCGA-22-5479	LUSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.T176K	DO27287	LUSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.G160C	TCGA-49-6743	LUAD	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.G160C	DO26092	LUAD	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.S164Y	TCGA-BA-A6DA	HNSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.3056
p.S164Y	DO44448	HNSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.3056
p.T171A	TCGA-CV-7407	HNSC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.7139
p.T171A	DO15711	HNSC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.7139
p.I156V	TCGA-EO-A3KX	UCEC	TCGA	DSGIEMT	DEG_SCF_TRCP1_1	0.0833
p.I156V	DO219774	UCEC	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.0833
p.L169I	DO229006	LICA	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.7174
p.E177K	DO218280	ORCA	ICGC	DSGIEMT	DEG_SCF_TRCP1_1	0.1667
p.E177K	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	0.1667
p.E177K	SIDM01679	Small Cell Lung Carcinoma	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	0.1667
p.E169D	SIDM00291	Melanoma	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	0.5647
p.E169D	ACH-002040	Skin Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	0.5647
p.E169D	HMV-II	skin	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.5647
p.T176M	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.T176M	ACH-000922	Leukemia	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.T176M	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.1944
p.V155L	ACH-000830	Lung Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	0.0556
p.V155L	NCI-H1436	lung	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.0556
p.V178E	ACH-000979	Prostate Cancer	CCLE	DSGIEMT	DEG_SCF_TRCP1_1	0.1389
p.V178E	DU-145	prostate	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.1389
p.V170L	NCI-H1436	lung	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.6765
p.H179Y	HEC-1	endometrium	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.1111
p.D166G	SNU-1040	large_intestine	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.7198
p.A169V	SNU-81	large_intestine	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.6936
p.T155I	TE-9	oesophagus	COSMIC	DSGIEMT	DEG_SCF_TRCP1_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGIEMT

Degron related mutations and impact score

Drug responses associated with RTN1 mutations

All proteins holding degron of DSGIEMT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_TRCP1_1	165:171	DSGIEMT	BTRC	0.9956	More...