DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SCF_FBW7_1

Location: 143:149

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 73.3286

COIL: 0.9523

CONS_SCORE: 0.3607

DSS_SCORE: 0.7273

HELIX: 0.0284

FCONS_SCORE: 1.1328

RIG_SCORE: 0.5965

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P146H	TCGA-05-4382	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.7694
p.P146H	DO24900	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.7694
p.G144C	TCGA-17-Z053	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.6489
p.G147V	TCGA-55-7994	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.6421
p.G147V	DO45311	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.6421
p.P148S	TCGA-91-6836	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.5641
p.P148S	DO23854	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.5641
p.E141K	TCGA-AC-A23H	BRCA	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.E141K	DO2401	BRCA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.E142K	TCGA-DA-A95X	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.3056
p.E142K	DO219480	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.3056
p.D152Y	TCGA-DK-A6AW	BLCA	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.D152Y	DO48566	BLCA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.I156V	TCGA-EO-A3KX	UCEC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.1389
p.I156V	DO219774	UCEC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.1389
p.S137L	TCGA-YG-AA3N	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.1667
p.S137L	DO51298	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.1667
p.P148T	DO229018	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.5919
p.P148T	DO229041	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.5919
p.P148T	ACH-000775	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.5919
p.P148T	NCI-H727	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.5919
p.P153T	DO229022	LICA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2222
p.P153S	DO26560	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2222
p.P153S	DO51407	PRAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2222
p.V154E	DO45462	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.1944
p.G133S	DO52023	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.0556
p.T151I	DO50119	STAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.A134T	DO38727	STAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.0833
p.P148H	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.6583
p.P148H	ACH-000860	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.6583
p.P148H	NCI-H358	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.6583
p.G147C	SIDM00507	Other Solid Cancers	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.6489
p.G147C	ACH-001490	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.6489
p.G147C	COR-L321	NS	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.6489
p.T145A	SIDM00871	Non-Cancerous	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.825
p.T145A	SIDM00872	Breast Carcinoma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.825
p.T140I	ACH-000694	Esophageal Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.T140I	TE-9	oesophagus	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.V155L	ACH-000830	Lung Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.1667
p.V155L	NCI-H1436	lung	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.1667
p.T155I	TE-9	oesophagus	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_FBW7_1	143:149	LGTPGPS	FBXW7	0.999	More...
Q99687	Homeobox protein Meis3	DEG_SCF_FBW7_1	215:221	LGTPGPS	FBXW7	0.9896	More...
A6NDR6	Putative homeobox protein Meis3-like 1	DEG_SCF_FBW7_1	114:120	LGTPGPS	FBXW7	0.912	More...
A8K0S8	Putative homeobox protein Meis3-like 2	DEG_SCF_FBW7_1	198:204	LGTPGPS	FBXW7	0.7944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGTPGPS

Degron related mutations and impact score

Drug responses associated with RTN1 mutations

All proteins holding degron of LGTPGPS