DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LGTPGPS
Uniprot ID:
A8K0S8
Source protein:
Putative homeobox protein Meis3-like 2
Source gene:
MEIS3P2
Class:
DEG_SCF_FBW7_1
Location:
198:204
E3 ligase:
FBXW7
DEGRON score:
0.7944
ASA_SCORE:
47.0571
COIL:
0.8143
CONS_SCORE:
0.5814
DSS_SCORE:
0.6916
HELIX:
0.0473
FCONS_SCORE:
0.9561
RIG_SCORE:
0.5565
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MEIS3P2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LGTPGPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q16799
Reticulon-1
DEG_SCF_FBW7_1
143:149
LGTPGPS
FBXW7
0.999
More...
Q99687
Homeobox protein Meis3
DEG_SCF_FBW7_1
215:221
LGTPGPS
FBXW7
0.9896
More...
A6NDR6
Putative homeobox protein Meis3-like 1
DEG_SCF_FBW7_1
114:120
LGTPGPS
FBXW7
0.912
More...
A8K0S8
Putative homeobox protein Meis3-like 2
DEG_SCF_FBW7_1
198:204
LGTPGPS
FBXW7
0.7944
More...