DegronMD

Uniprot ID: Q99687

Source protein: Homeobox protein Meis3

Source gene: MEIS3

Class: DEG_SCF_FBW7_1

Location: 215:221

E3 ligase: FBXW7

DEGRON score: 0.9896

ASA_SCORE: 51.6714

COIL: 0.8187

CONS_SCORE: 0.347

DSS_SCORE: 0.733

HELIX: 0.0404

FCONS_SCORE: 1.0672

RIG_SCORE: 0.5389

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S212Y	TCGA-19-5956	GBM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.S212Y	DO13863	GBM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.G223R	TCGA-49-6767	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.G223R	DO23586	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.S221A	TCGA-D1-A3JP	UCEC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.7588
p.S221A	DO219769	UCEC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.7588
p.H207N	TCGA-EE-A181	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.1111
p.H207N	DO37444	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.1111
p.S222I	TCGA-NC-A5HJ	LUSC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	0.3056
p.S222I	DO219189	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.3056
p.P220L	DO220877	MELA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.6471
p.P220L	DO222837	MELA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	0.6471
p.G224D	SIDM01662	Plasma Cell Myeloma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.25
p.G223V	SIDM01662	Plasma Cell Myeloma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	0.2778
p.A226S	ACH-000887	Brain Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	0.1944
p.S229F	H513	pleura	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_FBW7_1	143:149	LGTPGPS	FBXW7	0.999	More...
Q99687	Homeobox protein Meis3	DEG_SCF_FBW7_1	215:221	LGTPGPS	FBXW7	0.9896	More...
A6NDR6	Putative homeobox protein Meis3-like 1	DEG_SCF_FBW7_1	114:120	LGTPGPS	FBXW7	0.912	More...
A8K0S8	Putative homeobox protein Meis3-like 2	DEG_SCF_FBW7_1	198:204	LGTPGPS	FBXW7	0.7944	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons