DegronMD - Q99687(MEIS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S212Y	TCGA-19-5956	GBM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.S212Y	DO13863	GBM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.G223R	TCGA-49-6767	LUAD	TCGA	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.G223R	DO23586	LUAD	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.S221A	TCGA-D1-A3JP	UCEC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.7588
p.S221A	DO219769	UCEC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.7588
p.H207N	TCGA-EE-A181	SKCM	TCGA	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1111
p.H207N	DO37444	SKCM	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1111
p.S222I	TCGA-NC-A5HJ	LUSC	TCGA	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.3056
p.S222I	DO219189	LUSC	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.3056
p.P220L	DO220877	MELA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.6471
p.P220L	DO222837	MELA	ICGC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.6471
p.G224D	SIDM01662	Plasma Cell Myeloma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.G223V	SIDM01662	Plasma Cell Myeloma	GDSC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.A226S	ACH-000887	Brain Cancer	CCLE	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1944
p.S229F	H513	pleura	COSMIC	LGTPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1111

Kaplan plot for MEIS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MEIS3

UniProt ID: Q99687

Entrez ID: 56917

Protein name: Homeobox protein Meis3 (Meis1-related protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MEIS3 in