DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SCF_SKP2-CKS1_1

Location: 296:303

E3 ligase: SKP2,CSK1

DEGRON score: 0.9789

ASA_SCORE: 109.8875

COIL: 0.8601

CONS_SCORE: 0.3456

DSS_SCORE: 0.6467

HELIX: 0.12

FCONS_SCORE: 0.8949

RIG_SCORE: 0.7194

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T286M	TCGA-06-5408	GBM	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T286M	TCGA-AA-3492	COAD	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T286M	DO8224	COAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T286M	DO12862	GBM	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.T296N	TCGA-23-1118	OV	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5944
p.T296N	DO30220	OV	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5944
p.Q304E	TCGA-37-A5EM	LUSC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.Q304E	DO223719	LUSC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.3056
p.S311T	TCGA-AA-3663	COAD	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.S311T	DO9346	COAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1111
p.P290H	TCGA-AP-A051	UCEC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.P290H	DO42673	UCEC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1667
p.L308I	TCGA-AP-A1DV	UCEC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.L308I	DO43186	UCEC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.E289Q	TCGA-EK-A2RB	CESC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E289Q	DO48989	CESC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.E302K	TCGA-EK-A2RK	CESC	TCGA	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.591
p.E302K	DO49952	CESC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.591
p.E298Q	DO218173	BRCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.6744
p.P312H	DO227980	COCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E298G	DO234363	ESAD	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7199
p.K299N	DO228941	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM00615	Hepatocellular Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM00611	Kidney Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM00498	Colorectal Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM00616	Hepatocellular Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.K299N	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.5806
p.P310T	DO229019	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1389
p.T286K	DO229038	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0556
p.I306T	DO50954	LICA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.25
p.L308V	DO231078	LUSC	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.1944
p.S291F	DO220875	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.6389
p.E287K	DO222653	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.E287D	DO222875	MELA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.0833
p.C307F	DO232016	ORCA	ICGC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.2222
p.K303N	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.6918
p.K303N	ACH-000893	Lung Cancer	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.6918
p.K303N	NCI-H1651	lung	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.6918
p.P301T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P301T	ACH-000945	Lung Cancer	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7031
p.P301T	NCI-H650	lung	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7031
p.E298K	ACH-001982	Metastasis	CCLE	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7022
p.A297T	OACM5-1	oesophagus	COSMIC	TQEKTPEK	DEG_SCF_SKP2-CKS1_1	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TQEKTPEK

Degron related mutations and impact score

Drug responses associated with RTN1 mutations

All proteins holding degron of TQEKTPEK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_SKP2-CKS1_1	296:303	TQEKTPEK	SKP2,CSK1	0.9789	More...