DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SCF_FBW7_1

Location: 331:336

E3 ligase: FBXW7

DEGRON score: 0.9558

ASA_SCORE: 82.3667

COIL: 0.9643

CONS_SCORE: 0.3416

DSS_SCORE: 0.8603

HELIX: 0.0143

FCONS_SCORE: 0.8024

RIG_SCORE: 0.5384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D326N	TCGA-06-5416	GBM	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.1944
p.D326N	DO10880	GBM	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.1944
p.G329V	TCGA-50-5930	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.G329V	DO25189	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.P340R	TCGA-86-7713	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.2222
p.P340R	DO24712	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.2222
p.P340T	TCGA-86-7713	LUAD	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.2222
p.P340T	DO24712	LUAD	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.2222
p.P323S	TCGA-AX-A0J1	UCEC	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.1111
p.P323S	DO41199	UCEC	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.1111
p.E339G	TCGA-BC-A216	LIHC	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.25
p.E339G	DO22929	LIHC	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.25
p.E339K	TCGA-D3-A8GL	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.25
p.E339K	DO50287	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.25
p.S345F	TCGA-DA-A1HW	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.0833
p.S345F	DO229387	BTCA	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.0833
p.S345F	DO38129	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.0833
p.G337E	TCGA-EE-A2MS	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.3056
p.G337E	DO37567	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.3056
p.E322K	TCGA-EE-A2MS	SKCM	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.0833
p.E322K	DO37567	SKCM	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.0833
p.G329E	TCGA-VS-A959	CESC	TCGA	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.G329E	DO51640	CESC	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.G329E	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.G329E	ACH-000916	Lung Cancer	CCLE	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.G329E	NCI-H1573	lung	COSMIC	ITPPSS	DEG_SCF_FBW7_1	0.2778
p.T332N	DO229026	LICA	ICGC	ITPPSS	DEG_SCF_FBW7_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	DEG_SCF_FBW7_1	331:336	ITPPSS	FBXW7	0.9558	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_SCF_FBW7_1	1058:1063	ITPPSS	FBXW7	0.9894	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons