DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: DEG_SPOP_SBC_1

Location: 292:296

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 103.04

COIL: 0.932

CONS_SCORE: 0.3263

DSS_SCORE: 0.6388

HELIX: 0.0418

FCONS_SCORE: 0.8345

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T286M	TCGA-06-5408	GBM	TCGA	VETTT	DEG_SPOP_SBC_1	0.1667
p.T286M	TCGA-AA-3492	COAD	TCGA	VETTT	DEG_SPOP_SBC_1	0.1667
p.T286M	DO8224	COAD	ICGC	VETTT	DEG_SPOP_SBC_1	0.1667
p.T286M	DO12862	GBM	ICGC	VETTT	DEG_SPOP_SBC_1	0.1667
p.T296N	TCGA-23-1118	OV	TCGA	VETTT	DEG_SPOP_SBC_1	0.7055
p.T296N	DO30220	OV	ICGC	VETTT	DEG_SPOP_SBC_1	0.7055
p.Q304E	TCGA-37-A5EM	LUSC	TCGA	VETTT	DEG_SPOP_SBC_1	0.1111
p.Q304E	DO223719	LUSC	ICGC	VETTT	DEG_SPOP_SBC_1	0.1111
p.P290H	TCGA-AP-A051	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	0.2778
p.P290H	DO42673	UCEC	ICGC	VETTT	DEG_SPOP_SBC_1	0.2778
p.E289Q	TCGA-EK-A2RB	CESC	TCGA	VETTT	DEG_SPOP_SBC_1	0.25
p.E289Q	DO48989	CESC	ICGC	VETTT	DEG_SPOP_SBC_1	0.25
p.T294N	DO228974	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	0.7055
p.T286K	DO229038	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	0.1667
p.I306T	DO50954	LICA	ICGC	VETTT	DEG_SPOP_SBC_1	0.0556
p.S291F	DO220875	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	0.75
p.E287K	DO222653	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	0.1944
p.E287D	DO222875	MELA	ICGC	VETTT	DEG_SPOP_SBC_1	0.1944
p.T284P	SIDM02059	Colorectal Carcinoma	GDSC	VETTT	DEG_SPOP_SBC_1	0.1111
p.L285P	SIDM01060	Melanoma	GDSC	VETTT	DEG_SPOP_SBC_1	0.1389
p.L285P	ACH-000882	Skin Cancer	CCLE	VETTT	DEG_SPOP_SBC_1	0.1389
p.L285P	IGR-1	skin	COSMIC	VETTT	DEG_SPOP_SBC_1	0.1389
p.A285T	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	0.1389
p.S293L	LC-2-ad	lung	COSMIC	VETTT	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43310	CBP80/20-dependent translation initiation factor	DEG_SPOP_SBC_1	362:366	VETTT	SPOP	0.8922	More...
P34741	Syndecan-2	DEG_SPOP_SBC_1	86:90	VETTT	SPOP	0.9964	More...
Q16799	Reticulon-1	DEG_SPOP_SBC_1	292:296	VETTT	SPOP	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons