DegronMD - O43310(CTIF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q371H	TCGA-4Z-AA86	BLCA	TCGA	VETTT	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.3056
p.Q371H	DO218989	BLCA	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.3056
p.V364M	TCGA-A5-A0VP	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.7208
p.D375G	TCGA-B7-5816	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.D375G	DO38599	STAD	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0833
p.E361K	TCGA-FR-A7U9	SKCM	TCGA	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.E361K	DO48546	SKCM	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.3056
p.R352Q	TCGA-VQ-A8DU	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.R352Q	DO51752	STAD	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.K374N	DO50669	ORCA	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.2222
p.T366M	DO232940	PEME	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.7423
p.V362M	DO42600	UCEC	ICGC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation altering degron motif	0.7208
p.K376E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.K376E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation rewiring degron network	0.0556
p.K374E	ACH-002256	Leukemia	CCLE	VETTT	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.2222
p.K374E	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	362:366	Mutation substituting flanking lysine	0.2222

Kaplan plot for CTIF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTIF

UniProt ID: O43310

Entrez ID: 9811

Protein name: CBP80/20-dependent translation initiation factor

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTIF in