DegronMD

Uniprot ID: O43310

Source protein: CBP80/20-dependent translation initiation factor

Source gene: CTIF

Class: DEG_SPOP_SBC_1

Location: 362:366

E3 ligase: SPOP

DEGRON score: 0.8922

ASA_SCORE: 87.86

COIL: 0.864

CONS_SCORE: 0.3217

DSS_SCORE: 0.5506

HELIX: 0.0904

FCONS_SCORE: 0.7629

RIG_SCORE: 0.7539

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q371H	TCGA-4Z-AA86	BLCA	TCGA	VETTT	DEG_SPOP_SBC_1	0.3056
p.Q371H	DO218989	BLCA	ICGC	VETTT	DEG_SPOP_SBC_1	0.3056
p.V364M	TCGA-A5-A0VP	UCEC	TCGA	VETTT	DEG_SPOP_SBC_1	0.7208
p.D375G	TCGA-B7-5816	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	0.0833
p.D375G	DO38599	STAD	ICGC	VETTT	DEG_SPOP_SBC_1	0.0833
p.E361K	TCGA-FR-A7U9	SKCM	TCGA	VETTT	DEG_SPOP_SBC_1	0.3056
p.E361K	DO48546	SKCM	ICGC	VETTT	DEG_SPOP_SBC_1	0.3056
p.R352Q	TCGA-VQ-A8DU	STAD	TCGA	VETTT	DEG_SPOP_SBC_1	0.0556
p.R352Q	DO51752	STAD	ICGC	VETTT	DEG_SPOP_SBC_1	0.0556
p.K374N	DO50669	ORCA	ICGC	VETTT	DEG_SPOP_SBC_1	0.2222
p.T366M	DO232940	PEME	ICGC	VETTT	DEG_SPOP_SBC_1	0.7423
p.V362M	DO42600	UCEC	ICGC	VETTT	DEG_SPOP_SBC_1	0.7208
p.K376E	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VETTT	DEG_SPOP_SBC_1	0.0556
p.K376E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	0.0556
p.K374E	ACH-002256	Leukemia	CCLE	VETTT	DEG_SPOP_SBC_1	0.2222
p.K374E	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VETTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43310	CBP80/20-dependent translation initiation factor	DEG_SPOP_SBC_1	362:366	VETTT	SPOP	0.8922	More...
P34741	Syndecan-2	DEG_SPOP_SBC_1	86:90	VETTT	SPOP	0.9964	More...
Q16799	Reticulon-1	DEG_SPOP_SBC_1	292:296	VETTT	SPOP	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons