DegronMD

Uniprot ID: Q16799

Source protein: Reticulon-1

Source gene: RTN1

Class: LIG_APCC_ABBA_1

Location: 260:265

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9597

ASA_SCORE: 81.05

COIL: 0.7383

CONS_SCORE: 0.3743

DSS_SCORE: 0.4782

HELIX: 0.2145

FCONS_SCORE: 1.1959

RIG_SCORE: 0.8018

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D266N	TCGA-18-3409	LUSC	TCGA	FAPYID	LIG_APCC_ABBA_1	0.3056
p.D266N	DO26444	LUSC	ICGC	FAPYID	LIG_APCC_ABBA_1	0.3056
p.D266N	SIDM00663	Melanoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.3056
p.D266N	ACH-000814	Skin Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	0.3056
p.D266N	Hs939-T	skin	COSMIC	FAPYID	LIG_APCC_ABBA_1	0.3056
p.E256K	TCGA-3N-A9WD	SKCM	TCGA	FAPYID	LIG_APCC_ABBA_1	0.2222
p.E256K	DO51235	SKCM	ICGC	FAPYID	LIG_APCC_ABBA_1	0.2222
p.S268F	TCGA-43-6647	LUSC	TCGA	FAPYID	LIG_APCC_ABBA_1	0.25
p.S268F	DO26514	LUSC	ICGC	FAPYID	LIG_APCC_ABBA_1	0.25
p.E256Q	TCGA-AG-A020	READ	TCGA	FAPYID	LIG_APCC_ABBA_1	0.2222
p.E256Q	DO36451	READ	ICGC	FAPYID	LIG_APCC_ABBA_1	0.2222
p.I264T	TCGA-C5-A1ME	CESC	TCGA	FAPYID	LIG_APCC_ABBA_1	0.5966
p.I264T	DO49878	CESC	ICGC	FAPYID	LIG_APCC_ABBA_1	0.5966
p.S258F	TCGA-CG-5721	STAD	TCGA	FAPYID	LIG_APCC_ABBA_1	0.2778
p.S258F	DO38192	STAD	ICGC	FAPYID	LIG_APCC_ABBA_1	0.2778
p.F260L	TCGA-CK-4951	COAD	TCGA	FAPYID	LIG_APCC_ABBA_1	0.587
p.F260L	DO10582	COAD	ICGC	FAPYID	LIG_APCC_ABBA_1	0.587
p.R273K	TCGA-IB-7651	PAAD	TCGA	FAPYID	LIG_APCC_ABBA_1	0.1111
p.R273K	DO46657	PAAD	ICGC	FAPYID	LIG_APCC_ABBA_1	0.1111
p.R272C	DO233736	GACA	ICGC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272C	SIDM00783	Colorectal Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272C	ACH-000971	Colon/Colorectal Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	0.1389
p.Q271K	DO229038	LICA	ICGC	FAPYID	LIG_APCC_ABBA_1	0.1667
p.R272H	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM00773	Non-Cancerous	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM00845	Burkitt's Lymphoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM00493	Other Solid Cancers	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM01686	Chronic Myelogenous Leukemia	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.R272H	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.Y263C	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.7087
p.Y263C	ACH-000823	Esophageal Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	0.7087
p.Y263C	KYSE-140	oesophagus	COSMIC	FAPYID	LIG_APCC_ABBA_1	0.7087
p.H253Y	SIDM00596	Endometrial Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.H253Y	ACH-001517	Endometrial/Uterine Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	0.1389
p.H253Y	HEC-1	endometrium	COSMIC	FAPYID	LIG_APCC_ABBA_1	0.1389
p.E270K	SIDM00488	Colorectal Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1944
p.E270K	SIDM00169	Head and Neck Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1944
p.E270K	SIDM01588	Endometrial Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1944
p.E270K	SIDM01442	Glioma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.1944
p.A261T	SIDM00045	Gastric Carcinoma	GDSC	FAPYID	LIG_APCC_ABBA_1	0.6028
p.A261T	ACH-002141	Gastric Cancer	CCLE	FAPYID	LIG_APCC_ABBA_1	0.6028
p.A261T	HSC-39	stomach	COSMIC	FAPYID	LIG_APCC_ABBA_1	0.6028
p.G255E	NCI-H1573	lung	COSMIC	FAPYID	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FAPYID

Degron related mutations and impact score

Drug responses associated with RTN1 mutations

All proteins holding degron of FAPYID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16799	Reticulon-1	LIG_APCC_ABBA_1	260:265	FAPYID	APC,CDC20,FZR1	0.9597	More...