DegronMD

Uniprot ID: Q9BY89

Source protein: Uncharacterized protein KIAA1671

Source gene: KIAA1671

Class: DEG_APCC_KENBOX_2

Location: 669:673

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7067

ASA_SCORE: 113.5

COIL: 0.8758

CONS_SCORE: 0.3771

DSS_SCORE: 0.7218

HELIX: 0.0904

FCONS_SCORE: 0.9595

RIG_SCORE: 0.6529

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K667Q	DO222798	COCA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.2778
p.G659C	DO228952	LICA	ICGC	KKENS	DEG_APCC_KENBOX_2	0.0556
p.S673F	DO228398	PRAD	ICGC	KKENS	DEG_APCC_KENBOX_2	0.7982
p.D661N	SIDM01090	Colorectal Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	SIDM00200	Ewing's Sarcoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	SIDM00875	Breast Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	SIDM00032	Bladder Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	SIDM00720	Mesothelioma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	SCaBER	urinary_tract	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	NCI-H28	pleura	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	EW-12	bone	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	RKO	large_intestine	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.D661N	HCC1806	breast	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1111
p.P679S	SIDM00003	Melanoma	GDSC	KKENS	DEG_APCC_KENBOX_2	0.1667
p.P679S	M14	skin	COSMIC	KKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15151	Protein Mdm4	DEG_APCC_KENBOX_2	379:383	KKENS	APC,CDC20,FZR1	0.6013	More...
O60242	Adhesion G protein-coupled receptor B3	DEG_APCC_KENBOX_2	1271:1275	KKENS	APC,CDC20,FZR1	0.6429	More...
P29965	CD40 ligand	DEG_APCC_KENBOX_2	106:110	KKENS	APC,CDC20,FZR1	0.7872	More...
P56715	Oxygen-regulated protein 1	DEG_APCC_KENBOX_2	534:538	KKENS	APC,CDC20,FZR1	0.6968	More...
P98082	Disabled homolog 2	DEG_APCC_KENBOX_2	320:324	KKENS	APC,CDC20,FZR1	0.6959	More...
Q7Z2Z1	Treslin	DEG_APCC_KENBOX_2	887:891	KKENS	APC,CDC20,FZR1	0.9836	More...
Q9GZS3	WD repeat-containing protein 61	DEG_APCC_KENBOX_2	28:32	KKENS	APC,CDC20,FZR1	0.5187	More...
Q9NQW8	Cyclic nucleotide-gated cation channel beta-3	DEG_APCC_KENBOX_2	702:706	KKENS	APC,CDC20,FZR1	0.5372	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	381:385	KKENS	APC,CDC20,FZR1	0.9602	More...
Q9BY89	Uncharacterized protein KIAA1671	DEG_APCC_KENBOX_2	669:673	KKENS	APC,CDC20,FZR1	0.7067	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons