DegronMD - P56715(RP1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1767S	TCGA-05-4244	LUAD	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7588
p.A1767S	TCGA-06-1802	GBM	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7588
p.A1767S	DO12100	GBM	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7588
p.A1767S	DO23553	LUAD	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7588
p.D1354N	TCGA-21-1079	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.D1354N	DO228126	EOPC	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.D1354N	DO26846	LUSC	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.V1338A	TCGA-33-4532	LUSC	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.V1338A	DO26626	LUSC	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.L209R	TCGA-38-4631	LUAD	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.8428
p.L209R	DO24970	LUAD	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.8428
p.S1771L	TCGA-39-5028	LUSC	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7667
p.S1771L	TCGA-66-2770	LUSC	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7667
p.S1771L	DO26442	LUSC	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7667
p.S1771L	DO27556	LUSC	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7667
p.L1776I	TCGA-3B-A9I1	SARC	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1944
p.L1776I	DO219941	SARC	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1944
p.D524E	TCGA-44-2656	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.0556
p.D524E	DO26052	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.0556
p.L1345F	TCGA-44-8120	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.L1345F	TCGA-QB-AA9O	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.L1345F	DO45402	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.L1345F	DO51267	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.L531F	TCGA-49-AAR4	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.25
p.L531F	DO218920	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.25
p.T1359S	TCGA-50-5066	LUAD	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1111
p.T1359S	DO25040	LUAD	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1111
p.R533I	TCGA-55-7911	LUAD	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.3056
p.R533I	DO24821	LUAD	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.3056
p.R204M	TCGA-5M-AAT6	COAD	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.7521
p.R204M	DO223703	COAD	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.7521
p.Q525E	TCGA-61-1727	OV	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.0833
p.Q525E	DO29960	OV	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.0833
p.Q1602H	TCGA-98-A538	LUSC	TCGA	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1389
p.Q1602H	DO219177	LUSC	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1389
p.T1769I	TCGA-A5-A0G2	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7078
p.T1769I	DO41235	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation altering degron motif	0.7078
p.R193H	TCGA-A5-A2K5	UCEC	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.R193H	TCGA-AJ-A3BH	UCEC	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.R193H	DO41638	UCEC	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.R193H	DO41379	UCEC	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.S1757L	TCGA-AA-3685	COAD	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.0556
p.S1757L	DO8047	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.0556
p.D1343N	TCGA-AN-A041	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2222
p.D1343N	DO5625	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2222
p.S1780N	TCGA-AP-A059	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.0833
p.S1780N	DO41361	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.0833
p.D1357Y	TCGA-AX-A2HC	UCEC	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.D1357Y	DO41572	UCEC	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.L209I	TCGA-BF-A5EQ	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6063
p.L209I	DO219452	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6063
p.W1591C	TCGA-CN-A6V3	HNSC	TCGA	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.2778
p.W1591C	DO52050	HNSC	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.2778
p.E1698K	TCGA-CV-7568	HNSC	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1111
p.E1698K	DO14160	HNSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1111
p.R1700I	TCGA-D1-A16X	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0556
p.R1700I	DO41799	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0556
p.T1353I	TCGA-D3-A3ML	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.T1353I	DO47413	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.K534E	TCGA-D3-A8GI	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.591
p.K534E	DO50284	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.591
p.G203R	TCGA-D3-A8GK	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203R	DO50286	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203R	SIDM01608	Endometrial Carcinoma	GDSC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203R	SIDM01442	Glioma	GDSC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203R	ACH-000807	Brain Cancer	CCLE	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203R	ACH-000990	Endometrial/Uterine Cancer	CCLE	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6457
p.G203E	TCGA-D9-A6EC	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6087
p.G203E	DO220901	MELA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6087
p.G203E	DO229453	SKCA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6087
p.G203E	DO50291	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6087
p.E1695K	TCGA-DA-A3F3	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1944
p.E1695K	TCGA-YD-A9TA	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1944
p.E1695K	DO37607	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1944
p.E1695K	DO219503	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.1944
p.S1347F	TCGA-DA-A95Z	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6871
p.S1347F	TCGA-E2-A574	BRCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6871
p.S1347F	DO49022	BRCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6871
p.S1347F	DO219481	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6871
p.L1693F	TCGA-DK-A1A7	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.25
p.L1693F	DO483	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.25
p.L1693F	DO228948	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.25
p.E1601D	TCGA-DU-6392	LGG	TCGA	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1667
p.E1601D	DO22237	LGG	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1667
p.E1349K	TCGA-EB-A3Y7	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.7022
p.E1349K	DO229456	SKCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.7022
p.E1349K	DO37499	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.7022
p.D1357E	TCGA-EE-A20C	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.D1357E	DO222775	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.D1357E	DO47665	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.E536K	TCGA-EE-A2A2	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.7022
p.E536K	TCGA-EE-A3JD	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.7022
p.E536K	DO220902	MELA	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.7022
p.E536K	DO37583	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.7022
p.E536K	DO50299	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.7022
p.P1761L	TCGA-EE-A2GI	SKCM	TCGA	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1667
p.P1761L	DO37410	SKCM	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1667
p.S530L	TCGA-EE-A2MC	SKCM	TCGA	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.2222
p.S530L	DO37559	SKCM	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.2222
p.E1360K	TCGA-EE-A2MD	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.E1360K	DO222434	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.E1360K	DO37851	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.E1360K	SIDM01059	Melanoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.E1360K	ACH-000915	Skin Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.E1360K	IPC-298	skin	COSMIC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.D799N	TCGA-EE-A2MJ	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.2778
p.D799N	DO38099	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.2778
p.L1345I	TCGA-EE-A2MR	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.L1345I	DO37819	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.2778
p.E1699K	TCGA-EE-A3AF	SKCM	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0833
p.E1699K	DO37911	SKCM	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0833
p.S1683Y	TCGA-ET-A2N4	THCA	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.25
p.S1683Y	DO39415	THCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.25
p.P803S	TCGA-FW-A3R5	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.6752
p.P803S	DO37406	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.6752
p.P803S	SIDM00890	Melanoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.6752
p.P803S	ACH-000580	Skin Cancer	CCLE	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.6752
p.P803S	C32	skin	COSMIC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.6752
p.P1586L	TCGA-FW-A3R5	SKCM	TCGA	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1389
p.P1586L	DO37406	SKCM	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.1389
p.R1595W	TCGA-GF-A6C9	SKCM	TCGA	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.8634
p.R1595W	DO222843	MELA	ICGC	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.8634
p.R1595W	DO51254	SKCM	ICGC	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.8634
p.D1357N	TCGA-GN-A269	SKCM	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.D1357N	DO37483	SKCM	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.C1339F	TCGA-KQ-A41Q	BLCA	TCGA	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1111
p.C1339F	DO223591	BLCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1111
p.Q192K	TCGA-MI-A75I	LIHC	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.0833
p.Q192K	DO49712	LIHC	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.0833
p.I213F	TCGA-NC-A5HN	LUSC	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.2222
p.I213F	DO52025	LUSC	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.2222
p.E1684K	TCGA-Q1-A73O	CESC	TCGA	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.2778
p.E1684K	DO51612	CESC	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.2778
p.R193C	TCGA-QK-A6IG	HNSC	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.R193C	DO233882	GACA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.R193C	DO50002	HNSC	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.1111
p.V212M	TCGA-V5-A7RE	ESCA	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.25
p.V212M	TCGA-YG-AA3O	SKCM	TCGA	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.25
p.V212M	DO51299	SKCM	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.25
p.E806K	TCGA-W3-AA1V	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.7022
p.E806K	DO51276	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation altering degron motif	0.7022
p.S1691P	DO230334	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO229010	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO229016	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO229005	COCA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO234285	ESAD	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO229346	LAML	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO228947	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.S1691P	DO230524	LUSC	ICGC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.3056
p.I213T	DO50354	ESAD	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.2222
p.E1349G	DO48314	ESCA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.7199
p.D1773V	DO228771	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.2778
p.N537K	DO233000	GACA	ICGC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation altering degron motif	0.6918
p.I795F	DO233203	GACA	ICGC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1667
p.K1348N	DO233689	GACA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.6918
p.S1598I	DO233698	GACA	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.25
p.V219M	DO233726	GACA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.0556
p.D1597N	DO14171	HNSC	ICGC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.2778
p.D1593Y	DO228667	LICA	ICGC	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.7325
p.M191I	DO228986	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.0556
p.M191I	DO229029	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.0556
p.V1338F	DO229034	LICA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.0833
p.V212L	DO229009	LICA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.25
p.A200T	DO48682	LIRI	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation rewiring degron network	0.3056
p.K1605E	DO229177	LMS	ICGC	DYR	CBL_MET	1593:1595	Mutation substituting flanking lysine	0.1667
p.S812N	DO220866	MELA	ICGC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1667
p.R205K	DO220877	MELA	ICGC	TDGRRVPSL	DEG_COP1_1	201:209	Mutation altering degron motif	0.6126
p.T1341I	DO222710	MELA	ICGC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1667
p.I1349T	SIDM02074	Esophageal Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation altering degron motif	0.7078
p.F1344L	SIDM00967	Ovarian Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.F1344L	SIDM00844	Burkitt's Lymphoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.25
p.N1766H	SIDM00695	Melanoma	GDSC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.3056
p.N1766H	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.3056
p.P1761H	SIDM00282	Colorectal Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1667
p.P1761H	ACH-000998	Colon/Colorectal Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1667
p.P1761H	CW-2	large intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.1667
p.C1764S	SIDM00965	Small Cell Lung Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.25
p.C1764S	ACH-000800	Lung Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.25
p.C1764S	NCI-H446	lung	COSMIC	ADTTS	DEG_SPOP_SBC_1	1767:1771	Mutation rewiring degron network	0.25
p.S1358L	SIDM00562	Breast Carcinoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1389
p.S1358L	ACH-002163	Breast Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1389
p.S1358L	MRK-nu-1	breast	COSMIC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1389
p.Y1594C	SIDM00599	Osteosarcoma	GDSC	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.7087
p.Y1594C	ACH-001526	Bone Cancer	CCLE	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.7087
p.Y1594C	HuO9	bone	COSMIC	DYR	CBL_MET	1593:1595	Mutation altering degron motif	0.7087
p.I1342T	SIDM00126	Melanoma	GDSC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1944
p.I1342T	ACH-002147	Skin Cancer	CCLE	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1944
p.I1342T	K2	skin	COSMIC	SKENT	DEG_APCC_KENBOX_2	1347:1351	Mutation rewiring degron network	0.1944
p.I1583L	SIDM00927	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.0556
p.I1583L	ACH-000871	Lung Cancer	CCLE	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.0556
p.I1583L	NCI-H510A	lung	COSMIC	DYR	CBL_MET	1593:1595	Mutation rewiring degron network	0.0556
p.G1677W	SIDM00863	Burkitt's Lymphoma	GDSC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0833
p.G1677W	ACH-001064	Lymphoma	CCLE	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0833
p.G1677W	EB2	haematopoietic and lymphoid tissue	COSMIC	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.0833
p.S812I	SIDM00118	Colorectal Carcinoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1667
p.S812I	HCC2998	large intestine	COSMIC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1667
p.S542P	SIDM00901	Endometrial Carcinoma	GDSC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.2222
p.S542P	ACH-000940	Endometrial/Uterine Cancer	CCLE	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.2222
p.S542P	AN3-CA	endometrium	COSMIC	KKENS	DEG_APCC_KENBOX_2	534:538	Mutation rewiring degron network	0.2222
p.G796D	SIDM01503	Small Cell Lung Carcinoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1944
p.G796D	ACH-000844	Lung Cancer	CCLE	VFPHNE	LIG_APCC_ABBA_1	801:806	Mutation rewiring degron network	0.1944
p.Q1694K	ACH-001495	Endometrial/Uterine Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	1686:1690	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RP1

UniProt ID: P56715

Entrez ID: 6101

Protein name: Oxygen-regulated protein 1 (Retinitis pigmentosa 1 protein) (Retinitis pigmentosa RP1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RP1 in