DegronMD

Uniprot ID: P56715

Source protein: Oxygen-regulated protein 1

Source gene: RP1

Class: LIG_APCC_ABBA_1

Location: 801:806

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8723

ASA_SCORE: 104.9833

COIL: 0.8127

CONS_SCORE: 0.4253

DSS_SCORE: 0.4066

HELIX: 0.1387

FCONS_SCORE: 0.9779

RIG_SCORE: 0.7343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D799N	TCGA-EE-A2MJ	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	0.2778
p.D799N	DO38099	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	0.2778
p.P803S	TCGA-FW-A3R5	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	0.6752
p.P803S	DO37406	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	0.6752
p.P803S	SIDM00890	Melanoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	0.6752
p.P803S	ACH-000580	Skin Cancer	CCLE	VFPHNE	LIG_APCC_ABBA_1	0.6752
p.P803S	C32	skin	COSMIC	VFPHNE	LIG_APCC_ABBA_1	0.6752
p.E806K	TCGA-W3-AA1V	SKCM	TCGA	VFPHNE	LIG_APCC_ABBA_1	0.7022
p.E806K	DO51276	SKCM	ICGC	VFPHNE	LIG_APCC_ABBA_1	0.7022
p.I795F	DO233203	GACA	ICGC	VFPHNE	LIG_APCC_ABBA_1	0.1667
p.S812N	DO220866	MELA	ICGC	VFPHNE	LIG_APCC_ABBA_1	0.1667
p.S812I	SIDM00118	Colorectal Carcinoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	0.1667
p.S812I	HCC2998	large_intestine	COSMIC	VFPHNE	LIG_APCC_ABBA_1	0.1667
p.G796D	SIDM01503	Small Cell Lung Carcinoma	GDSC	VFPHNE	LIG_APCC_ABBA_1	0.1944
p.G796D	ACH-000844	Lung Cancer	CCLE	VFPHNE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	LIG_APCC_ABBA_1	801:806	VFPHNE	APC,CDC20,FZR1	0.8723	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons