DegronMD

Uniprot ID: P56715

Source protein: Oxygen-regulated protein 1

Source gene: RP1

Class: DEG_SPOP_SBC_1

Location: 1767:1771

E3 ligase: SPOP

DEGRON score: 0.9891

ASA_SCORE: 63.18

COIL: 0.7688

CONS_SCORE: 0.8276

DSS_SCORE: 0.5254

HELIX: 0.1048

FCONS_SCORE: 1.1935

RIG_SCORE: 0.7296

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1767S	TCGA-05-4244	LUAD	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7588
p.A1767S	TCGA-06-1802	GBM	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7588
p.A1767S	DO12100	GBM	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7588
p.A1767S	DO23553	LUAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7588
p.S1771L	TCGA-39-5028	LUSC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7667
p.S1771L	TCGA-66-2770	LUSC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7667
p.S1771L	DO26442	LUSC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7667
p.S1771L	DO27556	LUSC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7667
p.L1776I	TCGA-3B-A9I1	SARC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.1944
p.L1776I	DO219941	SARC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.1944
p.T1769I	TCGA-A5-A0G2	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7078
p.T1769I	DO41235	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7078
p.S1757L	TCGA-AA-3685	COAD	TCGA	ADTTS	DEG_SPOP_SBC_1	0.0556
p.S1757L	DO8047	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.0556
p.S1780N	TCGA-AP-A059	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.0833
p.S1780N	DO41361	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.0833
p.P1761L	TCGA-EE-A2GI	SKCM	TCGA	ADTTS	DEG_SPOP_SBC_1	0.1667
p.P1761L	DO37410	SKCM	ICGC	ADTTS	DEG_SPOP_SBC_1	0.1667
p.D1773V	DO228771	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2778
p.N1766H	SIDM00695	Melanoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.3056
p.N1766H	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.3056
p.P1761H	SIDM00282	Colorectal Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.1667
p.P1761H	ACH-000998	Colon/Colorectal Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	0.1667
p.P1761H	CW-2	large_intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.1667
p.C1764S	SIDM00965	Small Cell Lung Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.25
p.C1764S	ACH-000800	Lung Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	0.25
p.C1764S	NCI-H446	lung	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	DEG_SPOP_SBC_1	1767:1771	ADTTS	SPOP	0.9891	More...
Q14203	Dynactin subunit 1	DEG_SPOP_SBC_1	101:105	ADTTS	SPOP	0.9714	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1403:1407	ADTTS	SPOP	0.9997	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	645:649	ADTTS	SPOP	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTTS

Degron related mutations and impact score

Drug responses associated with RP1 mutations

All proteins holding degron of ADTTS