DegronMD

Uniprot ID: Q15652

Source protein: Probable JmjC domain-containing histone demethylation protein 2C

Source gene: JMJD1C

Class: DEG_SPOP_SBC_1

Location: 1403:1407

E3 ligase: SPOP

DEGRON score: 0.9997

ASA_SCORE: 77.66

COIL: 0.839

CONS_SCORE: 0.3334

DSS_SCORE: 0.3637

HELIX: 0.0928

FCONS_SCORE: 1.0191

RIG_SCORE: 0.7925

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1410G	TCGA-BC-4073	LIHC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.25
p.T1394A	TCGA-CG-5721	STAD	TCGA	ADTTS	DEG_SPOP_SBC_1	0.0833
p.D1404N	TCGA-E6-A8L9	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.5821
p.G1412V	TCGA-GM-A2DH	BRCA	TCGA	ADTTS	DEG_SPOP_SBC_1	0.1944
p.S1405P	DO225081	BRCA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.6752
p.S1405P	DO52559	BRCA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.6752
p.N1395I	DO8722	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2222
p.R1401I	DO8264	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2778
p.R1401I	DO41758	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2778
p.T1402I	DO14798	HNSC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.3056
p.G1410R	DO50970	LICA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.25
p.K1393T	DO23216	LINC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.0556
p.E1408D	DO26433	LUSC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.3056
p.S1405F	DO222743	MELA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7982
p.G1406V	DO229066	PRAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7532
p.T1394S	SIDM00741	Small Cell Lung Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.0833
p.G1413D	SIDM00883	Non-Cancerous	GDSC	ADTTS	DEG_SPOP_SBC_1	0.1667
p.G1413D	ACH-002382	Non-Cancerous	CCLE	ADTTS	DEG_SPOP_SBC_1	0.1667
p.V1393L	NCI-H747	large_intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	DEG_SPOP_SBC_1	1767:1771	ADTTS	SPOP	0.9891	More...
Q14203	Dynactin subunit 1	DEG_SPOP_SBC_1	101:105	ADTTS	SPOP	0.9714	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1403:1407	ADTTS	SPOP	0.9997	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	645:649	ADTTS	SPOP	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons