DegronMD

Uniprot ID: Q9H9B1

Source protein: Histone-lysine N-methyltransferase EHMT1

Source gene: EHMT1

Class: DEG_SPOP_SBC_1

Location: 645:649

E3 ligase: SPOP

DEGRON score: 0.9939

ASA_SCORE: 70.08

COIL: 0.819

CONS_SCORE: 0.4966

DSS_SCORE: 0.5492

HELIX: 0.0628

FCONS_SCORE: 1.162

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E658K	TCGA-DX-A8BP	SARC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.0833
p.E658K	DO220056	SARC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.0833
p.T641A	TCGA-PK-A5HB	ACC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T641M	DO233245	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T641M	DO45299	LIRI	ICGC	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T641M	SIDM01042	Breast Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T641M	ACH-001065	Breast Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T641M	EVSA-T	breast	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.2222
p.T640M	HCT-15	large_intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	DEG_SPOP_SBC_1	1767:1771	ADTTS	SPOP	0.9891	More...
Q14203	Dynactin subunit 1	DEG_SPOP_SBC_1	101:105	ADTTS	SPOP	0.9714	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1403:1407	ADTTS	SPOP	0.9997	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	645:649	ADTTS	SPOP	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons