DegronMD - Q14203(DCTN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G100A	TCGA-55-A48Y	LUAD	TCGA	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1667
p.G100A	TCGA-55-A48Y	LUAD	TCGA	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.3056
p.G100A	TCGA-55-A48Y	LUAD	TCGA	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.3056
p.G100A	DO26160	LUAD	ICGC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation rewiring degron network	0.1667
p.G100A	DO26160	LUAD	ICGC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.3056
p.G100A	DO26160	LUAD	ICGC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.3056
p.R90C	TCGA-60-2713	LUSC	TCGA	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.2222
p.R90C	DO233935	GACA	ICGC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.2222
p.R90C	DO26476	LUSC	ICGC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.2222
p.D110Y	TCGA-85-8350	LUSC	TCGA	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6214
p.D110Y	DO45492	LUSC	ICGC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6214
p.S111Y	TCGA-A5-A0G2	UCEC	TCGA	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.712
p.S111Y	DO41235	UCEC	ICGC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.712
p.T103I	TCGA-AP-A059	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7078
p.T103I	DO41361	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7078
p.D102N	TCGA-AZ-4315	COAD	TCGA	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.5821
p.D102N	DO8842	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.5821
p.P186T	TCGA-CZ-4853	KIRC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7031
p.S180N	TCGA-E6-A2P9	UCEC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.E182K	TCGA-EE-A2GI	SKCM	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.3056
p.A187T	TCGA-EY-A2OP	UCEC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.6028
p.P209R	TCGA-G3-AAV6	LIHC	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1389
p.P190S	TCGA-GN-A266	SKCM	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.3056
p.P190S	TCGA-GN-A266	SKCM	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.P194A	TCGA-L5-A8NI	ESCA	TCGA	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.1944
p.P194A	TCGA-L5-A8NI	ESCA	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.3056
p.P106L	TCGA-N8-A4PN	UCS	TCGA	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation altering degron motif	0.6471
p.D206H	DO225278	BRCA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.2222
p.P206L	DO227987	COCA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.2222
p.V204L	DO234394	ESAD	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.2778
p.V190F	DO234450	ESAD	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.3056
p.V190F	DO234450	ESAD	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.K115E	DO234425	ESAD	ICGC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation blocking ubiquitination signal	0.6944
p.K115E	DO234425	ESAD	ICGC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation blocking ubiquitination signal	0.5
p.A101T	DO233260	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation altering degron motif	0.7139
p.H85N	DO228952	LICA	ICGC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.0833
p.P199T	DO228974	LICA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7031
p.T122N	DO228971	LICA	ICGC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation blocking phosphorylation signal	0.5
p.P186Q	DO229034	LICA	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7035
p.P192Q	DO229041	LICA	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.25
p.P192Q	DO229041	LICA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.P189R	DO52299	LIHC	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7512
p.P183S	DO37432	SKCM	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.6752
p.S173N	DO43714	UCEC	ICGC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.0556
p.P199L	ACH-000939	Sarcoma	CCLE	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7582
p.R91W	SNG-M	endometrium	COSMIC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation rewiring degron network	0.0556
p.R91W	SNG-M	endometrium	COSMIC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.25
p.R205W	SNG-M	endometrium	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.E84G	JHH-6	liver	COSMIC	IQVFED	LIG_APCC_ABBA_1	94:99	Mutation rewiring degron network	0.0556
p.E201G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7199
p.R115W	SNU-C2B	large intestine	COSMIC	PETPDSS	DEG_SCF_FBW7_1	106:112	Mutation blocking ubiquitination signal	0.6944
p.R115W	SNU-C2B	large intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	101:105	Mutation blocking ubiquitination signal	0.5
p.R208W	SNG-M	endometrium	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1667
p.R183Q	BFTC-909	kidney	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.7329
p.R188W	SNG-M	endometrium	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation altering degron motif	0.8634
p.E181G	JHH-6	liver	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	183:189	Mutation rewiring degron network	0.2778
p.E198G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7199
p.E211G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.0833

Kaplan plot for DCTN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DCTN1

UniProt ID: Q14203

Entrez ID: 1639

Protein name: Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (DAP-150) (DP-150) (p135) (p150-glued)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DCTN1 in