DegronMD

Uniprot ID: Q14203

Source protein: Dynactin subunit 1

Source gene: DCTN1

Class: DEG_SCF_FBW7_1

Location: 183:189

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 90.3143

COIL: 0.9409

CONS_SCORE: 0.3854

DSS_SCORE: 0.6688

HELIX: 0.027

FCONS_SCORE: 1.1352

RIG_SCORE: 0.5921

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P186T	TCGA-CZ-4853	KIRC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.7031
p.S180N	TCGA-E6-A2P9	UCEC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.25
p.E182K	TCGA-EE-A2GI	SKCM	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.3056
p.A187T	TCGA-EY-A2OP	UCEC	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.6028
p.P190S	TCGA-GN-A266	SKCM	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.3056
p.P194A	TCGA-L5-A8NI	ESCA	TCGA	PSTPAQT	DEG_SCF_FBW7_1	0.1944
p.V190F	DO234450	ESAD	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.3056
p.P186Q	DO229034	LICA	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.7035
p.P192Q	DO229041	LICA	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.25
p.P189R	DO52299	LIHC	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.7512
p.P183S	DO37432	SKCM	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.6752
p.S173N	DO43714	UCEC	ICGC	PSTPAQT	DEG_SCF_FBW7_1	0.0556
p.R183Q	BFTC-909	kidney	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	0.7329
p.R188W	SNG-M	endometrium	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	0.8634
p.E181G	JHH-6	liver	COSMIC	PSTPAQT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14203	Dynactin subunit 1	DEG_SCF_FBW7_1	183:189	PSTPAQT	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons