DegronMD

Uniprot ID: Q14203

Source protein: Dynactin subunit 1

Source gene: DCTN1

Class: LIG_APCC_ABBA_1

Location: 94:99

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9455

ASA_SCORE: 82.55

COIL: 0.5105

CONS_SCORE: 0.3977

DSS_SCORE: 0.5282

HELIX: 0.0753

FCONS_SCORE: 0.8813

RIG_SCORE: 0.7846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100A	TCGA-55-A48Y	LUAD	TCGA	IQVFED	LIG_APCC_ABBA_1	0.3056
p.G100A	DO26160	LUAD	ICGC	IQVFED	LIG_APCC_ABBA_1	0.3056
p.R90C	TCGA-60-2713	LUSC	TCGA	IQVFED	LIG_APCC_ABBA_1	0.2222
p.R90C	DO233935	GACA	ICGC	IQVFED	LIG_APCC_ABBA_1	0.2222
p.R90C	DO26476	LUSC	ICGC	IQVFED	LIG_APCC_ABBA_1	0.2222
p.H85N	DO228952	LICA	ICGC	IQVFED	LIG_APCC_ABBA_1	0.0833
p.R91W	SNG-M	endometrium	COSMIC	IQVFED	LIG_APCC_ABBA_1	0.25
p.E84G	JHH-6	liver	COSMIC	IQVFED	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14203	Dynactin subunit 1	LIG_APCC_ABBA_1	94:99	IQVFED	APC,CDC20,FZR1	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons