DegronMD

Uniprot ID: Q14203

Source protein: Dynactin subunit 1

Source gene: DCTN1

Class: DEG_SCF_FBW7_1

Location: 195:202

E3 ligase: FBXW7

DEGRON score: 0.9947

ASA_SCORE: 99.575

COIL: 0.9535

CONS_SCORE: 0.354

DSS_SCORE: 0.5786

HELIX: 0.014

FCONS_SCORE: 1.0124

RIG_SCORE: 0.6905

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P209R	TCGA-G3-AAV6	LIHC	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	0.1389
p.P190S	TCGA-GN-A266	SKCM	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	0.1944
p.P194A	TCGA-L5-A8NI	ESCA	TCGA	IIPTPVLT	DEG_SCF_FBW7_1	0.3056
p.D206H	DO225278	BRCA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.2222
p.P206L	DO227987	COCA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.2222
p.V204L	DO234394	ESAD	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.2778
p.V190F	DO234450	ESAD	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.1944
p.P199T	DO228974	LICA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.7031
p.P192Q	DO229041	LICA	ICGC	IIPTPVLT	DEG_SCF_FBW7_1	0.25
p.P199L	ACH-000939	Sarcoma	CCLE	IIPTPVLT	DEG_SCF_FBW7_1	0.7582
p.R205W	SNG-M	endometrium	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	0.25
p.E201G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	0.7199
p.R208W	SNG-M	endometrium	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	0.1667
p.E198G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	0.7199
p.E211G	JHH-6	liver	COSMIC	IIPTPVLT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14203	Dynactin subunit 1	DEG_SCF_FBW7_1	195:202	IIPTPVLT	FBXW7	0.9947	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons