DegronMD

Uniprot ID: Q14203

Source protein: Dynactin subunit 1

Source gene: DCTN1

Class: DEG_SCF_FBW7_1

Location: 106:112

E3 ligase: FBXW7

DEGRON score: 0.8078

ASA_SCORE: 94.8714

COIL: 0.9101

CONS_SCORE: 0.3275

DSS_SCORE: 0.6681

HELIX: 0.0703

FCONS_SCORE: 0.9504

RIG_SCORE: 0.6392

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100A	TCGA-55-A48Y	LUAD	TCGA	PETPDSS	DEG_SCF_FBW7_1	0.1667
p.G100A	DO26160	LUAD	ICGC	PETPDSS	DEG_SCF_FBW7_1	0.1667
p.D110Y	TCGA-85-8350	LUSC	TCGA	PETPDSS	DEG_SCF_FBW7_1	0.6214
p.D110Y	DO45492	LUSC	ICGC	PETPDSS	DEG_SCF_FBW7_1	0.6214
p.S111Y	TCGA-A5-A0G2	UCEC	TCGA	PETPDSS	DEG_SCF_FBW7_1	0.712
p.S111Y	DO41235	UCEC	ICGC	PETPDSS	DEG_SCF_FBW7_1	0.712
p.P106L	TCGA-N8-A4PN	UCS	TCGA	PETPDSS	DEG_SCF_FBW7_1	0.6471
p.K115E	DO234425	ESAD	ICGC	PETPDSS	DEG_SCF_FBW7_1	0.6944
p.T122N	DO228971	LICA	ICGC	PETPDSS	DEG_SCF_FBW7_1	0.5
p.R115W	SNU-C2B	large_intestine	COSMIC	PETPDSS	DEG_SCF_FBW7_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14203	Dynactin subunit 1	DEG_SCF_FBW7_1	106:112	PETPDSS	FBXW7	0.8078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons