DegronMD

Uniprot ID: Q14203

Source protein: Dynactin subunit 1

Source gene: DCTN1

Class: DEG_SPOP_SBC_1

Location: 101:105

E3 ligase: SPOP

DEGRON score: 0.9714

ASA_SCORE: 90

COIL: 0.9698

CONS_SCORE: 0.2972

DSS_SCORE: 0.6494

HELIX: 0.0086

FCONS_SCORE: 0.7588

RIG_SCORE: 0.66

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100A	TCGA-55-A48Y	LUAD	TCGA	ADTTS	DEG_SPOP_SBC_1	0.3056
p.G100A	DO26160	LUAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.3056
p.T103I	TCGA-AP-A059	UCEC	TCGA	ADTTS	DEG_SPOP_SBC_1	0.7078
p.T103I	DO41361	UCEC	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7078
p.D102N	TCGA-AZ-4315	COAD	TCGA	ADTTS	DEG_SPOP_SBC_1	0.5821
p.D102N	DO8842	COAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.5821
p.K115E	DO234425	ESAD	ICGC	ADTTS	DEG_SPOP_SBC_1	0.5
p.A101T	DO233260	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	0.7139
p.R91W	SNG-M	endometrium	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.0556
p.R115W	SNU-C2B	large_intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P56715	Oxygen-regulated protein 1	DEG_SPOP_SBC_1	1767:1771	ADTTS	SPOP	0.9891	More...
Q14203	Dynactin subunit 1	DEG_SPOP_SBC_1	101:105	ADTTS	SPOP	0.9714	More...
Q15652	Probable JmjC domain-containing histone demethylation protein 2C	DEG_SPOP_SBC_1	1403:1407	ADTTS	SPOP	0.9997	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	645:649	ADTTS	SPOP	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons