DegronMD - Q9H9B1(EHMT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1296N	TCGA-2W-A8YY	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.D1296N	DO223732	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.D1296N	DO38388	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.G1285S	TCGA-3Z-A93Z	KIRC	TCGA	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2778
p.G1285S	DO219229	KIRC	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2778
p.G1285S	DO224541	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2778
p.G1285S	DO231003	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2778
p.Q1279P	TCGA-44-3918	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1111
p.Q1279P	DO23732	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1111
p.A1278S	TCGA-55-7576	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0833
p.A1278S	DO24431	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0833
p.E681G	TCGA-AP-A0LM	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.E681G	DO229250	THCA	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.E681G	DO43306	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0556
p.A662T	TCGA-B5-A3FC	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1944
p.A662T	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1944
p.E664G	TCGA-B5-A3FC	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.25
p.E664G	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.25
p.D668N	TCGA-BR-8680	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.5821
p.D668N	DO47769	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.5821
p.A675T	TCGA-CG-4305	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.2222
p.A675T	DO38823	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.2222
p.E658K	TCGA-DX-A8BP	SARC	TCGA	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.0833
p.E658K	TCGA-DX-A8BP	SARC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0833
p.E658K	DO220056	SARC	ICGC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.0833
p.E658K	DO220056	SARC	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.0833
p.T671M	TCGA-G3-AAV0	LIHC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	DO52294	LIHC	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	SIDM00789	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	ACH-000997	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	ACH-001061	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	ACH-001275	Sarcoma	CCLE	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.T671M	HCT-15	large intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7423
p.P677S	TCGA-IB-7651	PAAD	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1667
p.P677S	DO46657	PAAD	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1667
p.G672C	TCGA-OR-A5KB	ACC	TCGA	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.3056
p.T641A	TCGA-PK-A5HB	ACC	TCGA	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.A1292S	TCGA-ZS-A9CF	LIHC	TCGA	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.A1292S	DO49722	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.3056
p.S1290R	DO230319	COCA	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation altering degron motif	0.7427
p.S661L	DO227987	COCA	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.1667
p.A667T	DO233155	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation altering degron motif	0.7139
p.T641M	DO233245	GACA	ICGC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.T641M	DO45299	LIRI	ICGC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.T641M	SIDM01042	Breast Carcinoma	GDSC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.T641M	ACH-001065	Breast Cancer	CCLE	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.T641M	EVSA-T	breast	COSMIC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.2222
p.A1295S	DO229253	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2222
p.Q1282R	DO229253	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.A1277V	DO229216	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0556
p.S1291F	SIDM02038	Colorectal Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation altering degron motif	0.7982
p.E664V	SIDM01954	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.25
p.Q1279H	SIDM00120	Prostate Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1111
p.Q1279H	ACH-000979	Prostate Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1111
p.Q1279H	DU-145	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1111
p.A1277T	SIDM01043	Other Sarcomas	GDSC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0556
p.A1277T	ACH-000913	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0556
p.A1277T	ESS-1	endometrium	COSMIC	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0556
p.D1288N	ACH-000937	Leukemia	CCLE	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation altering degron motif	0.5821
p.E1283G	ACH-001509	Head and Neck Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.2222
p.T640M	HCT-15	large intestine	COSMIC	ADTTS	DEG_SPOP_SBC_1	645:649	Mutation rewiring degron network	0.1944
p.G674R	NCI-H378	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	667:671	Mutation rewiring degron network	0.25

Kaplan plot for EHMT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EHMT1

UniProt ID: Q9H9B1

Entrez ID: 79813

Protein name: Histone-lysine N-methyltransferase EHMT1 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a-like protein 1) (GLP) (GLP1) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Lysine N-methyltransferase 1D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EHMT1 in