DegronMD

Uniprot ID: Q9H9B1

Source protein: Histone-lysine N-methyltransferase EHMT1

Source gene: EHMT1

Class: DEG_SPOP_SBC_1

Location: 1287:1291

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 81.04

COIL: 0.7348

CONS_SCORE: 0.2373

DSS_SCORE: 0.7336

HELIX: 0.239

FCONS_SCORE: 1.0924

RIG_SCORE: 0.6415

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1296N	TCGA-2W-A8YY	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1944
p.D1296N	DO223732	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.D1296N	DO38388	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.G1285S	TCGA-3Z-A93Z	KIRC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.2778
p.G1285S	DO219229	KIRC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.G1285S	DO224541	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.G1285S	DO231003	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.Q1279P	TCGA-44-3918	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1111
p.Q1279P	DO23732	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.A1278S	TCGA-55-7576	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.0833
p.A1278S	DO24431	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.A1292S	TCGA-ZS-A9CF	LIHC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.3056
p.A1292S	DO49722	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.S1290R	DO230319	COCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7427
p.A1295S	DO229253	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.Q1282R	DO229253	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.A1277V	DO229216	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.S1291F	SIDM02038	Colorectal Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.7982
p.Q1279H	SIDM00120	Prostate Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.Q1279H	ACH-000979	Prostate Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.1111
p.Q1279H	DU-145	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.A1277T	SIDM01043	Other Sarcomas	GDSC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.A1277T	ACH-000913	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.0556
p.A1277T	ESS-1	endometrium	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.D1288N	ACH-000937	Leukemia	CCLE	PDTSS	DEG_SPOP_SBC_1	0.5821
p.E1283G	ACH-001509	Head and Neck Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons