DegronMD - Q9Y2E4(DIP2C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V143L	TCGA-44-8120	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.V143L	TCGA-CV-5436	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.Q144H	TCGA-D3-A3CE	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.T129I	TCGA-ER-A193	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.R88L	TCGA-FS-A1ZQ	SKCM	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.8428
p.S80L	TCGA-K4-A5RJ	BLCA	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.S80L	DO49784	BLCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.R78Q	TCGA-VQ-AA6D	STAD	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78Q	DO222392	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78Q	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78Q	ACH-001489	Lung Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78Q	COR-L32	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.G80R	DO445	BLCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.G80R	DO225283	BRCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.G80R	DO227940	BRCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1111
p.A126V	DO49095	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A126V	DO227985	COCA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.A126V	DO38599	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1944
p.V88I	DO234199	ESAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7076
p.D87N	DO13863	GBM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation blocking phosphorylation signal	0.75
p.A81T	DO22295	LGG	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.T125K	DO228974	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.T125K	DO229027	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1667
p.S79Y	DO229027	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0833
p.T121K	DO229031	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0556
p.L134I	DO229035	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7174
p.Y129H	DO45299	LIRI	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.M89I	DO27096	LUSC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7618
p.E133K	DO35290	PACA	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7022
p.E133K	DO43891	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7022
p.S123F	DO37567	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.P101S	DO50288	SKCM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.P101S	DO47672	SKCM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.G122R	DO48665	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.V88A	DO38404	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.6936
p.V103I	DO51761	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0833
p.A82T	DO229240	THCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1667
p.A132T	DO42280	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7139
p.V103L	DO43154	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0833
p.P101T	DO41488	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1389
p.R78L	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78L	ACH-000463	Lung Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.R78L	NCI-H460	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.0556
p.T93M	SIDM00789	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7423
p.T93M	ACH-000997	Colon/Colorectal Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7423
p.T93M	ACH-001061	Colon/Colorectal Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7423
p.T93M	HCT-15	large intestine	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7423
p.R86C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.R86C	ACH-001127	Leukemia	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.R86C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.2778
p.Y128H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.25
p.A127T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.R83Q	ACH-001991	Primary	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation rewiring degron network	0.1944
p.R129C	HCC1954	breast	COSMIC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2778
p.K88T	SW900	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation altering degron motif	0.7306
p.R142C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.R134L	NCI-H460	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.8428
p.R134Q	COR-L32	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7329
p.R87Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	88:94	Mutation blocking phosphorylation signal	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIP2C

UniProt ID: Q9Y2E4

Entrez ID: 22982

Protein name: Disco-interacting protein 2 homolog C (DIP2 homolog C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIP2C in