DegronMD

Uniprot ID: Q9Y2E4

Source protein: Disco-interacting protein 2 homolog C

Source gene: DIP2C

Class: DEG_SPOP_SBC_1

Location: 131:135

E3 ligase: SPOP

DEGRON score: 0.9451

ASA_SCORE: 82.02

COIL: 0.929

CONS_SCORE: 0.4165

DSS_SCORE: 0.7567

HELIX: 0.046

FCONS_SCORE: 0.9854

RIG_SCORE: 0.5809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V143L	TCGA-44-8120	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1111
p.V143L	TCGA-CV-5436	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1111
p.Q144H	TCGA-D3-A3CE	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.0833
p.T129I	TCGA-ER-A193	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.2778
p.A126V	DO49095	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.A126V	DO227985	COCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.A126V	DO38599	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.T125K	DO228974	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.T125K	DO229027	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.T121K	DO229031	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.L134I	DO229035	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7174
p.Y129H	DO45299	LIRI	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.E133K	DO35290	PACA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7022
p.E133K	DO43891	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7022
p.S123F	DO37567	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.G122R	DO48665	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.A132T	DO42280	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7139
p.Y128H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.25
p.A127T	ACH-001518	Endometrial/Uterine Cancer	CCLE	PDTSS	DEG_SPOP_SBC_1	0.2222
p.R129C	HCC1954	breast	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.R142C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.R134L	NCI-H460	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.8428
p.R134Q	COR-L32	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons