DegronMD - Q96A33(CCDC47)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I120V	TCGA-91-6840	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1389
p.I120V	DO23608	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1389
p.P119L	TCGA-BT-A0YX	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.P119L	DO516	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.S114R	TCGA-C5-A2LX	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.S114R	DO49004	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.S114R	DO229025	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.3056
p.M237I	TCGA-CF-A9FF	BLCA	TCGA	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.M237I	DO218999	BLCA	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.E103Q	TCGA-GC-A4ZW	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.E103Q	DO219024	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667
p.M218I	TCGA-MA-AA3Y	CESC	TCGA	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1111
p.M218I	DO219721	CESC	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1111
p.T111S	DO228205	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation altering degron motif	0.6005
p.T121K	DO229031	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1111
p.Q228K	DO229041	LICA	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.5833
p.D118E	DO229242	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1944
p.V241L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.V241L	ACH-000951	Lung Cancer	CCLE	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.V241L	NCI-H2342	lung	COSMIC	KRQDLLNVL	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.1389
p.F103L	SF268	central nervous system	COSMIC	PDTSS	DEG_SPOP_SBC_1	109:113	Mutation rewiring degron network	0.1667

Kaplan plot for CCDC47 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC47

UniProt ID: Q96A33

Entrez ID: 57003

Protein name: PAT complex subunit CCDC47 (Calumin) (Coiled-coil domain-containing protein 47)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC47 in