DegronMD

Uniprot ID: Q96A33

Source protein: PAT complex subunit CCDC47

Source gene: CCDC47

Class: DEG_SPOP_SBC_1

Location: 109:113

E3 ligase: SPOP

DEGRON score: 0.8466

ASA_SCORE: 88.06

COIL: 0.9282

CONS_SCORE: 0.247

DSS_SCORE: 0.6745

HELIX: 0.0514

FCONS_SCORE: 0.8696

RIG_SCORE: 0.6169

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I120V	TCGA-91-6840	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1389
p.I120V	DO23608	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.P119L	TCGA-BT-A0YX	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1667
p.P119L	DO516	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.S114R	TCGA-C5-A2LX	CESC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.3056
p.S114R	DO49004	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.S114R	DO229025	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.E103Q	TCGA-GC-A4ZW	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1667
p.E103Q	DO219024	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.T111S	DO228205	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.6005
p.T121K	DO229031	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.D118E	DO229242	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1944
p.F103L	SF268	central_nervous_system	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons