DegronMD

Uniprot ID: Q6PCT2

Source protein: F-box/LRR-repeat protein 19

Source gene: FBXL19

Class: DEG_SPOP_SBC_1

Location: 321:325

E3 ligase: SPOP

DEGRON score: 0.7927

ASA_SCORE: 100.56

COIL: 0.9484

CONS_SCORE: 0.5384

DSS_SCORE: 0.6972

HELIX: 0.0406

FCONS_SCORE: 0.7783

RIG_SCORE: 0.595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S326A	TCGA-06-2566	GBM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.3056
p.R319L	TCGA-64-5778	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.2778
p.D335N	TCGA-AX-A2HC	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.0556
p.L317M	TCGA-CN-6010	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.2222
p.S325Y	TCGA-D3-A2JP	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.712
p.S332F	TCGA-D6-6516	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1389
p.S328L	TCGA-S5-A6DX	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.25
p.S317L	DO219078	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.S317L	DO51259	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.S320L	DO457	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.S320L	DO222875	MELA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.E329K	DO3940	BRCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.E329K	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.R331Q	DO222574	BTCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.R335W	DO10550	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.S312F	DO15623	HNSC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.D315Y	DO229008	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.L321V	DO29920	OV	ICGC	PDTSS	DEG_SPOP_SBC_1	0.6765
p.R331W	DO37519	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.R331W	DO37408	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.D315N	DO41572	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.S324T	SIDM00969	Ovarian Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.6005
p.S324T	DOV13	ovary	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.6005
p.D333N	SIDM01619	Endometrial Carcinoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.G333V	NCI-H345	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.G333W	NCI-H345	lung	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.R327G	MDA-MB-415	breast	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons