DegronMD - Q14689(DIP2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H160R	TCGA-13-0800	OV	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.3056
p.H160R	DO28611	OV	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.3056
p.P165L	TCGA-24-2030	OV	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1667
p.P165L	DO30590	OV	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1667
p.V163I	TCGA-44-7670	LUAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.V163I	DO234230	ESAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.V163I	DO23555	LUAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.R88M	TCGA-91-6829	LUAD	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1944
p.R88M	DO23564	LUAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1944
p.S137L	TCGA-A5-A0G1	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.S137L	TCGA-B5-A11E	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.S137L	TCGA-CV-A461	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.S137L	DO49058	HNSC	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.S137L	DO41644	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.S137L	DO42472	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation altering degron motif	0.7667
p.A86V	TCGA-A5-A0G2	UCEC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1389
p.A86V	DO41235	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1389
p.R148Q	TCGA-AA-3833	COAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.R148Q	TCGA-AA-3833	COAD	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.0556
p.R148Q	DO9796	COAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.R148Q	DO9796	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.0556
p.D32G	TCGA-AG-A002	READ	TCGA	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1389
p.S126L	TCGA-AP-A1DV	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.S126L	TCGA-EE-A20F	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.S126L	DO37961	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.S126L	DO43186	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1111
p.R91C	TCGA-B5-A11E	UCEC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.2778
p.R91C	DO41644	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.2778
p.E90K	TCGA-BA-4076	HNSC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.25
p.E90K	DO14502	HNSC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.25
p.D168V	TCGA-CD-8529	STAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168V	DO47753	STAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.P133H	TCGA-D3-A8GB	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.P133H	DO50280	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.3056
p.S145C	TCGA-D8-A1XY	BRCA	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1389
p.S145C	TCGA-D8-A1XY	BRCA	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.S145C	DO1266	BRCA	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1389
p.S145C	DO1266	BRCA	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.V128M	TCGA-DI-A1BU	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667
p.V128M	DO42023	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1667
p.P149L	TCGA-EE-A29M	SKCM	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.25
p.P149L	DO37404	SKCM	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.25
p.P156L	TCGA-EE-A2GT	SKCM	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.7582
p.P156L	DO37946	SKCM	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.7582
p.P156L	SIDM00845	Burkitt's Lymphoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation altering degron motif	0.7582
p.R169W	TCGA-QQ-A8VF	SARC	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0556
p.R169W	DO220258	SARC	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0556
p.S145F	TCGA-SY-A9G5	BLCA	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1389
p.S145F	TCGA-SY-A9G5	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.S145F	DO51906	BLCA	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.1389
p.S145F	DO51906	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation rewiring degron network	0.1389
p.T132I	TCGA-UZ-A9PR	KIRP	TCGA	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation blocking phosphorylation signal	0.7222
p.T132I	DO219708	KIRP	ICGC	PDTSS	DEG_SPOP_SBC_1	134:138	Mutation blocking phosphorylation signal	0.7222
p.V101L	DO229028	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.2778
p.R88S	DO229025	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1944
p.A106S	DO229009	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.1389
p.V17G	DO46372	OV	ICGC	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation altering degron motif	0.6421
p.P12L	DO229242	THCA	ICGC	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation rewiring degron network	0.1944
p.A100T	SIDM02059	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.3056
p.A103T	SIDM02059	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation rewiring degron network	0.2222
p.D168N	SIDM00565	Oral Cavity Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168N	SIDM00375	Head and Neck Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168N	ACH-001626	Head and Neck Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168N	ACH-002305	Head and Neck Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168N	OSC-20	upper aerodigestive tract	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.D168N	SKN-3	upper aerodigestive tract	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0833
p.T98I	SIDM00992	Thyroid Gland Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation altering degron motif	0.7078
p.T98I	ACH-000456	Thyroid Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation altering degron motif	0.7078
p.T98I	BCPAP	thyroid	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	93:99	Mutation altering degron motif	0.7078
p.G150R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2778
p.G150R	ACH-000953	Leukemia	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2778
p.G150R	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2778
p.T34A	SIDM00333	Endometrial Carcinoma	GDSC	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5278
p.T34A	ACH-000988	Endometrial/Uterine Cancer	CCLE	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5278
p.T34A	MFE-319	endometrium	COSMIC	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5278
p.S162N	SIDM00683	Prostate Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation blocking phosphorylation signal	0.6944
p.S162N	LNCaP-Clone-FGC	prostate	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation blocking phosphorylation signal	0.6944
p.R169L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0556
p.R169L	ACH-000945	Lung Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0556
p.R169L	NCI-H650	lung	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.0556
p.V163A	SIDM01611	Endometrial Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.V163A	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	152:159	Mutation rewiring degron network	0.2222
p.E9D	ACH-000178	Pancreatic Cancer	CCLE	VRESLAELE	DEG_APCC_DBOX_1	17:25	Mutation blocking phosphorylation signal	0.5556
p.A194P	ACH-002131	Lung Cancer	CCLE	ASSTS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0556
p.A194P	H2803	pleura	COSMIC	ASSTS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DIP2A

UniProt ID: Q14689

Entrez ID: 23181

Protein name: Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DIP2A in