DegronMD

Uniprot ID: Q14689

Source protein: Disco-interacting protein 2 homolog A

Source gene: DIP2A

Class: DEG_APCC_DBOX_1

Location: 17:25

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7234

ASA_SCORE: 56.4111

COIL: 0.0313

CONS_SCORE: 0.166

DSS_SCORE: 0.342

HELIX: 0.9693

FCONS_SCORE: 1.0639

RIG_SCORE: 0.7897

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D32G	TCGA-AG-A002	READ	TCGA	VRESLAELE	DEG_APCC_DBOX_1	0.1389
p.V17G	DO46372	OV	ICGC	VRESLAELE	DEG_APCC_DBOX_1	0.6421
p.P12L	DO229242	THCA	ICGC	VRESLAELE	DEG_APCC_DBOX_1	0.1944
p.T34A	SIDM00333	Endometrial Carcinoma	GDSC	VRESLAELE	DEG_APCC_DBOX_1	0.5278
p.T34A	ACH-000988	Endometrial/Uterine Cancer	CCLE	VRESLAELE	DEG_APCC_DBOX_1	0.5278
p.T34A	MFE-319	endometrium	COSMIC	VRESLAELE	DEG_APCC_DBOX_1	0.5278
p.E9D	ACH-000178	Pancreatic Cancer	CCLE	VRESLAELE	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14689	Disco-interacting protein 2 homolog A	DEG_APCC_DBOX_1	17:25	VRESLAELE	APC,CDC20,FZR1	0.7234	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons