DegronMD

Uniprot ID: Q14689

Source protein: Disco-interacting protein 2 homolog A

Source gene: DIP2A

Class: LIG_APCC_ABBAyCdc20_2

Location: 93:99

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 87.1429

COIL: 0.5236

CONS_SCORE: 0.1138

DSS_SCORE: 0.569

HELIX: 0.4433

FCONS_SCORE: 1.016

RIG_SCORE: 0.7121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R88M	TCGA-91-6829	LUAD	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R88M	DO23564	LUAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A86V	TCGA-A5-A0G2	UCEC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A86V	DO41235	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R91C	TCGA-B5-A11E	UCEC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R91C	DO41644	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E90K	TCGA-BA-4076	HNSC	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.E90K	DO14502	HNSC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.25
p.V101L	DO229028	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R88S	DO229025	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A106S	DO229009	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A100T	SIDM02059	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A103T	SIDM02059	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2222
p.T98I	SIDM00992	Thyroid Gland Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7078
p.T98I	ACH-000456	Thyroid Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7078
p.T98I	BCPAP	thyroid	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14689	Disco-interacting protein 2 homolog A	LIG_APCC_ABBAyCdc20_2	93:99	RSDVHTE	APC,CDC20,FZR1	0.9914	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	LIG_APCC_ABBAyCdc20_2	88:94	RSDVHTE	APC,CDC20,FZR1	0.9171	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons