DegronMD

Uniprot ID: Q9Y2E4

Source protein: Disco-interacting protein 2 homolog C

Source gene: DIP2C

Class: LIG_APCC_ABBAyCdc20_2

Location: 88:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9171

ASA_SCORE: 86.1143

COIL: 0.4933

CONS_SCORE: 0.4159

DSS_SCORE: 0.5501

HELIX: 0.4829

FCONS_SCORE: 0.9743

RIG_SCORE: 0.7

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R88L	TCGA-FS-A1ZQ	SKCM	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.8428
p.S80L	TCGA-K4-A5RJ	BLCA	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.S80L	DO49784	BLCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R78Q	TCGA-VQ-AA6D	STAD	TCGA	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78Q	DO222392	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78Q	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78Q	ACH-001489	Lung Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78Q	COR-L32	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G80R	DO445	BLCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G80R	DO225283	BRCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G80R	DO227940	BRCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V88I	DO234199	ESAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7076
p.D87N	DO13863	GBM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.75
p.A81T	DO22295	LGG	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S79Y	DO229027	LICA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.M89I	DO27096	LUSC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7618
p.P101S	DO50288	SKCM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P101S	DO47672	SKCM	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V88A	DO38404	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.6936
p.V103I	DO51761	STAD	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A82T	DO229240	THCA	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1667
p.V103L	DO43154	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0833
p.P101T	DO41488	UCEC	ICGC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R78L	SIDM00144	Non-Small Cell Lung Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78L	ACH-000463	Lung Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R78L	NCI-H460	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T93M	SIDM00789	Colorectal Carcinoma	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7423
p.T93M	ACH-000997	Colon/Colorectal Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7423
p.T93M	ACH-001061	Colon/Colorectal Cancer	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7423
p.T93M	HCT-15	large_intestine	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7423
p.R86C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R86C	ACH-001127	Leukemia	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R86C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R83Q	ACH-001991	Primary	CCLE	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.1944
p.K88T	SW900	lung	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.7306
p.R87Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RSDVHTE	LIG_APCC_ABBAyCdc20_2	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14689	Disco-interacting protein 2 homolog A	LIG_APCC_ABBAyCdc20_2	93:99	RSDVHTE	APC,CDC20,FZR1	0.9914	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	LIG_APCC_ABBAyCdc20_2	88:94	RSDVHTE	APC,CDC20,FZR1	0.9171	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RSDVHTE

Degron related mutations and impact score

Drug responses associated with DIP2C mutations

All proteins holding degron of RSDVHTE