DegronMD

Uniprot ID: Q14689

Source protein: Disco-interacting protein 2 homolog A

Source gene: DIP2A

Class: DEG_SPOP_SBC_1

Location: 134:138

E3 ligase: SPOP

DEGRON score: 0.9885

ASA_SCORE: 86.94

COIL: 0.9398

CONS_SCORE: 0.1569

DSS_SCORE: 0.6581

HELIX: 0.0472

FCONS_SCORE: 1.0044

RIG_SCORE: 0.6041

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S137L	TCGA-A5-A0G1	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.7667
p.S137L	TCGA-B5-A11E	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.7667
p.S137L	TCGA-CV-A461	HNSC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.7667
p.S137L	DO49058	HNSC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7667
p.S137L	DO41644	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7667
p.S137L	DO42472	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7667
p.R148Q	TCGA-AA-3833	COAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.0556
p.R148Q	DO9796	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0556
p.S126L	TCGA-AP-A1DV	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1111
p.S126L	TCGA-EE-A20F	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1111
p.S126L	DO37961	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.S126L	DO43186	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.P133H	TCGA-D3-A8GB	SKCM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.3056
p.P133H	DO50280	SKCM	ICGC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.S145C	TCGA-D8-A1XY	BRCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1389
p.S145C	DO1266	BRCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.V128M	TCGA-DI-A1BU	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1667
p.V128M	DO42023	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.S145F	TCGA-SY-A9G5	BLCA	TCGA	PDTSS	DEG_SPOP_SBC_1	0.1389
p.S145F	DO51906	BLCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.T132I	TCGA-UZ-A9PR	KIRP	TCGA	PDTSS	DEG_SPOP_SBC_1	0.7222
p.T132I	DO219708	KIRP	ICGC	PDTSS	DEG_SPOP_SBC_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons