DegronMD

Uniprot ID: P36956

Source protein: Sterol regulatory element-binding protein 1

Source gene: SREBF1

Class: DEG_SPOP_SBC_1

Location: 64:68

E3 ligase: SPOP

DEGRON score: 0.999

ASA_SCORE: 77.8

COIL: 0.958

CONS_SCORE: 0.2915

DSS_SCORE: 0.7924

HELIX: 0.0194

FCONS_SCORE: 1.0942

RIG_SCORE: 0.5465

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F59Y	TCGA-55-8511	LUAD	TCGA	PDTSS	DEG_SPOP_SBC_1	0.6389
p.F59Y	DO24940	LUAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.6389
p.N68D	TCGA-A5-A0G1	UCEC	TCGA	PDTSS	DEG_SPOP_SBC_1	0.6932
p.A54S	TCGA-ZB-A966	THYM	TCGA	PDTSS	DEG_SPOP_SBC_1	0.0556
p.S63F	DO51632	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.75
p.P76A	DO6254	CESC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.A76T	DO8400	COAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.G58D	DO17801	KIRC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.S58G	DO20942	KIRP	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.G57R	DO44584	LGG	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.A62D	DO229041	LICA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2778
p.S68P	DO22959	LIHC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.6752
p.R71L	DO26695	LUSC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.25
p.I77T	DO219875	SKCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.R67H	DO38214	STAD	ICGC	PDTSS	DEG_SPOP_SBC_1	0.8244
p.T72I	DO229221	THCA	ICGC	PDTSS	DEG_SPOP_SBC_1	0.2222
p.R71H	DO43306	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.25
p.A55T	DO41871	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.0833
p.N75S	DO41235	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1389
p.P76H	DO41103	UCEC	ICGC	PDTSS	DEG_SPOP_SBC_1	0.1111
p.P74S	SIDM00190	Melanoma	GDSC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.P74S	CP66-MEL	skin	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.1667
p.P69T	ACH-000977	lymph_node	CCLE	PDTSS	DEG_SPOP_SBC_1	0.3056
p.P69T	LNCaP-Clone-FGC	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.3056
p.A62V	ACH-000977	lymph_node	CCLE	PDTSS	DEG_SPOP_SBC_1	0.2778
p.A62V	LNCaP-Clone-FGC	prostate	COSMIC	PDTSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	64:68	PDTSS	SPOP	0.999	More...
Q14689	Disco-interacting protein 2 homolog A	DEG_SPOP_SBC_1	134:138	PDTSS	SPOP	0.9885	More...
Q6PCT2	F-box/LRR-repeat protein 19	DEG_SPOP_SBC_1	321:325	PDTSS	SPOP	0.7927	More...
Q96A33	PAT complex subunit CCDC47	DEG_SPOP_SBC_1	109:113	PDTSS	SPOP	0.8466	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	1287:1291	PDTSS	SPOP	0.9968	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	2151:2155	PDTSS	SPOP	0.9929	More...
Q9P265	Disco-interacting protein 2 homolog B	DEG_SPOP_SBC_1	142:146	PDTSS	SPOP	0.9674	More...
Q9Y2E4	Disco-interacting protein 2 homolog C	DEG_SPOP_SBC_1	131:135	PDTSS	SPOP	0.9451	More...
Q8N485	Protein limb expression 1 homolog	DEG_SPOP_SBC_1	263:267	PDTSS	SPOP	0.8481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons