DegronMD

Uniprot ID: Q14689

Source protein: Disco-interacting protein 2 homolog A

Source gene: DIP2A

Class: DEG_SCF_FBW7_1

Location: 152:159

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 80.575

COIL: 0.8625

CONS_SCORE: 0.1532

DSS_SCORE: 0.6254

HELIX: 0.0866

FCONS_SCORE: 0.9961

RIG_SCORE: 0.6317

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H160R	TCGA-13-0800	OV	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.3056
p.H160R	DO28611	OV	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.3056
p.P165L	TCGA-24-2030	OV	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.1667
p.P165L	DO30590	OV	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.1667
p.V163I	TCGA-44-7670	LUAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.V163I	DO234230	ESAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.V163I	DO23555	LUAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.R148Q	TCGA-AA-3833	COAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.R148Q	DO9796	COAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.D168V	TCGA-CD-8529	STAD	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168V	DO47753	STAD	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.S145C	TCGA-D8-A1XY	BRCA	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.1389
p.S145C	DO1266	BRCA	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.1389
p.P149L	TCGA-EE-A29M	SKCM	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.25
p.P149L	DO37404	SKCM	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.25
p.P156L	TCGA-EE-A2GT	SKCM	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.7582
p.P156L	DO37946	SKCM	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.7582
p.P156L	SIDM00845	Burkitt's Lymphoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.7582
p.R169W	TCGA-QQ-A8VF	SARC	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.0556
p.R169W	DO220258	SARC	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.0556
p.S145F	TCGA-SY-A9G5	BLCA	TCGA	LTSTPLQS	DEG_SCF_FBW7_1	0.1389
p.S145F	DO51906	BLCA	ICGC	LTSTPLQS	DEG_SCF_FBW7_1	0.1389
p.D168N	SIDM00565	Oral Cavity Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168N	SIDM00375	Head and Neck Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168N	ACH-001626	Head and Neck Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168N	ACH-002305	Head and Neck Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168N	OSC-20	upper_aerodigestive_tract	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.D168N	SKN-3	upper_aerodigestive_tract	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	0.0833
p.G150R	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.2778
p.G150R	ACH-000953	Leukemia	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	0.2778
p.G150R	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	0.2778
p.S162N	SIDM00683	Prostate Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.6944
p.S162N	LNCaP-Clone-FGC	prostate	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	0.6944
p.R169L	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.0556
p.R169L	ACH-000945	Lung Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	0.0556
p.R169L	NCI-H650	lung	COSMIC	LTSTPLQS	DEG_SCF_FBW7_1	0.0556
p.V163A	SIDM01611	Endometrial Carcinoma	GDSC	LTSTPLQS	DEG_SCF_FBW7_1	0.2222
p.V163A	ACH-000996	Endometrial/Uterine Cancer	CCLE	LTSTPLQS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTSTPLQS

Degron related mutations and impact score

Drug responses associated with DIP2A mutations

All proteins holding degron of LTSTPLQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14689	Disco-interacting protein 2 homolog A	DEG_SCF_FBW7_1	152:159	LTSTPLQS	FBXW7	0.9987	More...