DegronMD

Uniprot ID: Q96A33

Source protein: PAT complex subunit CCDC47

Source gene: CCDC47

Class: DEG_APCC_DBOX_1

Location: 226:234

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6252

ASA_SCORE: 27.8

COIL: 0.347

CONS_SCORE: 0.5363

DSS_SCORE: 0.041

HELIX: 0.5929

FCONS_SCORE: 1.3216

RIG_SCORE: 0.9258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M237I	TCGA-CF-A9FF	BLCA	TCGA	KRQDLLNVL	DEG_APCC_DBOX_1	0.25
p.M237I	DO218999	BLCA	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	0.25
p.M218I	TCGA-MA-AA3Y	CESC	TCGA	KRQDLLNVL	DEG_APCC_DBOX_1	0.1111
p.M218I	DO219721	CESC	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	0.1111
p.Q228K	DO229041	LICA	ICGC	KRQDLLNVL	DEG_APCC_DBOX_1	0.5833
p.V241L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	KRQDLLNVL	DEG_APCC_DBOX_1	0.1389
p.V241L	ACH-000951	Lung Cancer	CCLE	KRQDLLNVL	DEG_APCC_DBOX_1	0.1389
p.V241L	NCI-H2342	lung	COSMIC	KRQDLLNVL	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96A33	PAT complex subunit CCDC47	DEG_APCC_DBOX_1	226:234	KRQDLLNVL	APC,CDC20,FZR1	0.6252	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons