DegronMD

Uniprot ID: Q9H9B1

Source protein: Histone-lysine N-methyltransferase EHMT1

Source gene: EHMT1

Class: DEG_SPOP_SBC_1

Location: 667:671

E3 ligase: SPOP

DEGRON score: 0.9939

ASA_SCORE: 71.84

COIL: 0.8514

CONS_SCORE: 0.4252

DSS_SCORE: 0.7083

HELIX: 0.0448

FCONS_SCORE: 1.0381

RIG_SCORE: 0.6581

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E681G	TCGA-AP-A0LM	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.0556
p.E681G	DO229250	THCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.E681G	DO43306	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.A662T	TCGA-B5-A3FC	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.A662T	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1944
p.E664G	TCGA-B5-A3FC	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.25
p.E664G	DO41871	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.25
p.D668N	TCGA-BR-8680	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.5821
p.D668N	DO47769	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.5821
p.A675T	TCGA-CG-4305	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.2222
p.A675T	DO38823	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.2222
p.E658K	TCGA-DX-A8BP	SARC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.0833
p.E658K	DO220056	SARC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.T671M	TCGA-G3-AAV0	LIHC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	DO52294	LIHC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	SIDM00789	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	ACH-000997	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	ACH-001061	Colon/Colorectal Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	ACH-001275	Sarcoma	CCLE	ADTTT	DEG_SPOP_SBC_1	0.7423
p.T671M	HCT-15	large_intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.7423
p.P677S	TCGA-IB-7651	PAAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1667
p.P677S	DO46657	PAAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1667
p.G672C	TCGA-OR-A5KB	ACC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.3056
p.S661L	DO227987	COCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1667
p.A667T	DO233155	GACA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.7139
p.E664V	SIDM01954	Colorectal Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.25
p.G674R	NCI-H378	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons