DegronMD

Uniprot ID: P39060

Source protein: Collagen alpha-1

Source gene: COL18A1

Class: DEG_SPOP_SBC_1

Location: 58:62

E3 ligase: SPOP

DEGRON score: 0.8165

ASA_SCORE: 76.16

COIL: 0.8192

CONS_SCORE: 0.3003

DSS_SCORE: 0.7891

HELIX: 0.071

FCONS_SCORE: 0.9573

RIG_SCORE: 0.632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R67G	TCGA-06-1802	GBM	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R67G	TCGA-GL-A59R	KIRP	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R67G	DO12100	GBM	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R67G	DO44525	KIRP	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1944
p.T65I	TCGA-EB-A3Y6	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	0.25
p.T65I	DO38081	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	0.25
p.R67W	TCGA-G4-6297	COAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R67W	DO9418	COAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1944
p.P48A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM00454	Rhabdomyosarcoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM00846	Cervical Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM00971	Breast Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM00254	Neuroblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM00808	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM01254	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.P48A	SIDM01525	Acute Myeloid Leukemia	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0556
p.Q49L	SIDM00969	Ovarian Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM00656	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM00879	Breast Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM00309	Mesothelioma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM00641	Burkitt's Lymphoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM01664	Prostate Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.Q49L	SIDM01387	Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.T59M	SNU-175	large_intestine	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTTT

Degron related mutations and impact score

Drug responses associated with COL18A1 mutations

All proteins holding degron of ADTTT