DegronMD

Uniprot ID: Q15059

Source protein: Bromodomain-containing protein 3

Source gene: BRD3

Class: DEG_SPOP_SBC_1

Location: 246:250

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 88.56

COIL: 0.9264

CONS_SCORE: 0.4257

DSS_SCORE: 0.6265

HELIX: 0.0372

FCONS_SCORE: 1.1965

RIG_SCORE: 0.6793

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G241S	TCGA-76-4934	GBM	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1944
p.G241S	DO12286	GBM	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1944
p.R244L	TCGA-78-7540	LUAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244L	DO23810	LUAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244Q	TCGA-AX-A2HA	UCEC	TCGA	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244Q	DO42504	UCEC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244Q	SIDM00999	Bladder Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244Q	ACH-000973	Bladder Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.2778
p.R244Q	639-V	urinary_tract	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.2778
p.D247N	SIDM00767	Small Cell Lung Carcinoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.5821
p.D247N	ACH-001136	Lung Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.5821
p.D247N	NCI-H187	lung	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.5821
p.S254L	ACH-001610	Brain Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.6667

Drug responses associated with BRD3 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	JQ1	0.3976
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	I-BET-762	1.2888
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	JQ1	7.6954
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	I-BET-762	5.6449
SIDM01077	PRAD\|prostate	p.K435Q (No)	GDSC	OTX015	1.3879
SIDM00592	HNSC\|head_and_neck	p.T250P (Yes)	GDSC	JQ1	1.573
SIDM00592	HNSC\|head_and_neck	p.T250P (Yes)	GDSC	I-BET-762	145.0807
SIDM00592	HNSC\|head_and_neck	p.T250P (Yes)	GDSC	JQ1	0.7392
SIDM00592	HNSC\|head_and_neck	p.T250P (Yes)	GDSC	I-BET-762	7.7874
SIDM00592	HNSC\|head_and_neck	p.T250P (Yes)	GDSC	OTX015	2.209
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	JQ1	2.3732
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	I-BET-762	71.5862
SIDM00240	CESC\|cervix	p.S27C (No)	GDSC	JQ1	2.1327
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	JQ1	1.2267
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	I-BET-762	194.4751
SIDM01164	LGG\|glioma	p.R578H (No)	GDSC	JQ1	9.0501
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	JQ1	0.4647
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	I-BET-762	104.9952
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	JQ1	16.1912
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	I-BET-762	2146.4
SIDM01188	PAAD\|pancreas	p.P23T (No)	GDSC	OTX015	2169.4
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	90.7099
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	16.3879
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	31.09
SIDM00498	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	11.312
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	JQ1	4.27
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	I-BET-762	364.9685
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	JQ1	3.2888
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	I-BET-762	310.95
SIDM01174	CESC\|cervix	p.H550_C554delHFLTC (No)	GDSC	OTX015	366.53
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	20.3215
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	12.192
SIDM00945	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	8.2232
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.295
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	2.3258
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.5738
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	13.928
SIDM00121	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	OTX015	8.6619
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	JQ1	0.7789
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	I-BET-762	2.6504
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	JQ1	11.3018
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	I-BET-762	2.6739
SIDM00683	PRAD\|prostate	p.V26G (No)	GDSC	OTX015	0.6869
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P24fs*24 (No)	GDSC	OTX015	27.581
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.E25fs*51 (No)	GDSC	OTX015	27.581
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	3.6348
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.P24fs*51 (No)	GDSC	OTX015	3.8966
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.8552
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	49.7156
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	12.0168
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	225.8
SIDM00334	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	363.36
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	8.7965
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	167.0381
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	19.234
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	75.068
SIDM00519	MESO\|mesothelioma	p.A172V (No)	GDSC	OTX015	68.795
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	JQ1	2.4783
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	I-BET-762	15.6496
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	JQ1	9.1283
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	I-BET-762	27.067
SIDM01078	SCLC\|lung_small_cell_carcinoma	p.K655R (No)	GDSC	OTX015	9.8305
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.V190I (No)	GDSC	OTX015	3.8966
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	I-BET-762	19.8372
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	JQ1	8.9937
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	I-BET-762	28.523
SIDM00537	COREAD\|large_intestine	p.A216fs*47 (No)	GDSC	OTX015	16.542
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.3119
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	19.8372
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	8.9937
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	28.523
SIDM00537	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	16.542
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	JQ1	0.4035
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	I-BET-762	149.4508
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	JQ1	13.1406
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	I-BET-762	62.026
SIDM01051	UNCLASSIFIED\|ovary	p.G717R (No)	GDSC	OTX015	84.708
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	JQ1	0.6311
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	I-BET-762	130.1398
SIDM00666	LGG\|glioma	p.K435Q (No)	GDSC	JQ1	11.3272
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	OTX015	12.366
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	JQ1	0.8435
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	I-BET-762	5.4856
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	JQ1	9.4619
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	I-BET-762	6.212
SIDM00312	MM\|myeloma	p.K435Q (No)	GDSC	OTX015	2.7912
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	JQ1	1.3207
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	I-BET-762	48.995
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	JQ1	11.2727
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	I-BET-762	18.636
SIDM01088	UNCLASSIFIED\|endometrium	p.R284H (No)	GDSC	OTX015	7.414
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	JQ1	0.3181
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	I-BET-762	34.4825
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	JQ1	8.7581
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	I-BET-762	92.689
SIDM00256	NB\|neuroblastoma	p.M383_F384delinsI (No)	GDSC	OTX015	86.672
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	JQ1	0.3151
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	I-BET-762	17.5293
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	JQ1	21.531
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	I-BET-762	38.752
SIDM00003	SKCM\|melanoma	p.S609F (No)	GDSC	OTX015	7.8185
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	JQ1	6.1996
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	I-BET-762	35.822
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	JQ1	8.1248
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	I-BET-762	24.728
SIDM00233	ALL\|lymphoblastic_T_cell_leukaemia	p.P266L (No)	GDSC	OTX015	55.321
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	22.7238
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	9.7528
SIDM00151	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	3.6257
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	JQ1	0.2493
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	I-BET-762	23.9838
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	JQ1	13.2791
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	I-BET-762	30.514
SIDM00418	THCA\|thyroid	p.K435Q (No)	GDSC	OTX015	20.307
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.8733
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	112.2983
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	8.3749
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	90.897
SIDM00373	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	23.288
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	0.8733
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	112.2983
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	8.3749
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	90.897
SIDM00373	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	OTX015	23.288
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	0.5022
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	1.8887
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	JQ1	2.2668
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	I-BET-762	4.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.P24fs*24 (No)	GDSC	OTX015	1.1727
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	JQ1	0.6789
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	I-BET-762	3.2635
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	JQ1	0.3499
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	I-BET-762	92.613
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.P232H (No)	GDSC	OTX015	27.581
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	JQ1	0.1798
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	I-BET-762	162.5679
SIDM00619	THCA\|thyroid	p.L70Q (No)	GDSC	JQ1	5.1804
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	JQ1	2.7961
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	I-BET-762	55.8606
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	JQ1	0.8454
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	I-BET-762	3.1806
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.V174M (No)	GDSC	OTX015	2.0707
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	JQ1	6.3107
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	I-BET-762	105.237
SIDM00251	STAD\|stomach	p.P24fs*24 (No)	GDSC	JQ1	4.1863
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (Yes)	GDSC	JQ1	7.5775
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (Yes)	GDSC	I-BET-762	66.8571
SIDM00767	SCLC\|lung_small_cell_carcinoma	p.D247N (Yes)	GDSC	JQ1	14.1677
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	0.9055
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	71.6074
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	JQ1	18.934
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	I-BET-762	102.22
SIDM00099	MESO\|mesothelioma	p.A172V (No)	GDSC	OTX015	43.237
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	JQ1	1.0155
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	I-BET-762	221.1497
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	JQ1	10.0186
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	I-BET-762	30.21
SIDM00853	UNCLASSIFIED\|soft_tissue_other	p.K435Q (No)	GDSC	OTX015	13.277
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	0.3232
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	0.8405
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	JQ1	7.5537
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	I-BET-762	5.202
SIDM00211	ALL\|lymphoblastic_leukemia	p.K435Q (No)	GDSC	OTX015	2.7833
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.1659
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	22.6909
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	8.3957
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	28.645
SIDM00783	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	7.6012
SIDM00999	BLCA\|bladder	p.R244Q (Yes)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R244Q (Yes)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R244Q (Yes)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R244Q (Yes)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R244Q (Yes)	GDSC	OTX015	21.915
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.R34H (No)	GDSC	OTX015	13.116
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	JQ1	1.2191
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	I-BET-762	225.1683
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	JQ1	13.9753
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	I-BET-762	34.459
SIDM00180	KIRC\|kidney	p.T36N (No)	GDSC	OTX015	23.587
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	JQ1	51.5138
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	I-BET-762	182.0816
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	JQ1	12.4468
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	I-BET-762	20.848
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.P234S (No)	GDSC	OTX015	21.788
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	3.4367
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	114.2188
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	4.869
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	260.84
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	OTX015	42.102
SIDM00933	BRCA\|breast	p.A172V (No)	GDSC	JQ1	40.792
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	JQ1	1.4121
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	I-BET-762	221.2172
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	JQ1	0.85
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	I-BET-762	214.41
SIDM00889	CESC\|cervix	p.K435Q (No)	GDSC	OTX015	122.61
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	JQ1	0.9507
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	I-BET-762	5.5114
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	JQ1	0.3938
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	I-BET-762	2.9656
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.K435Q (No)	GDSC	OTX015	0.6297
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	OTX015	0.925
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	1.1061
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	26.2956
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	1.7202
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	31.127
SIDM00111	GBM\|glioma	p.K435Q (No)	GDSC	OTX015	16.284
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	9.581
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	115.5562
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	JQ1	8.515
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	I-BET-762	4.1775
SIDM01074	GBM\|glioma	p.K435Q (No)	GDSC	OTX015	1.9351
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.E564G (No)	GDSC	OTX015	20.069
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.W96* (No)	GDSC	OTX015	20.069
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	1.3207
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	48.995
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	11.2727
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	18.636
SIDM01088	UNCLASSIFIED\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	7.414
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	JQ1	19.0116
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	I-BET-762	9.8986
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	JQ1	6.9964
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	I-BET-762	185.08
SIDM00469	PAAD\|pancreas	p.P23A (No)	GDSC	OTX015	136.47
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	JQ1	2.169
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	I-BET-762	20.4407
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	JQ1	6.5843
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	I-BET-762	24.87
SIDM00321	UNCLASSIFIED\|ovary	p.S715F (No)	GDSC	OTX015	28.588
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	JQ1	1.279
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	I-BET-762	1.1173
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	JQ1	0.5812
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	I-BET-762	3.9598
SIDM00886	DLBC\|B_cell_lymphoma	p.K435Q (No)	GDSC	OTX015	5.2314
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.E25fs*24 (No)	GDSC	OTX015	7.248
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	314.0424
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	14.1477
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	218.79
SIDM00238	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	100.87
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	JQ1	0.2912
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	I-BET-762	211.2221
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	JQ1	6.0328
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	I-BET-762	51.997
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.P24fs*24 (No)	GDSC	OTX015	11.089
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	0.7918
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	71.8478
SIDM00715	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	3.1436
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	2.622
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	44.2865
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	19.1166
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	14.161
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	OTX015	30.337
SIDM00954	BRCA\|breast	p.A172V (No)	GDSC	JQ1	8.3058
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	27.4948
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	56.9189
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	JQ1	5.0151
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	I-BET-762	25.97
SIDM00743	LUAD\|lung_NSCLC_adenocarcinoma	p.A172V (No)	GDSC	OTX015	13.61
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	0.5636
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	4.7421
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	JQ1	4.2649
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	I-BET-762	7.2251
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.P24fs*24 (No)	GDSC	OTX015	2.5363
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	JQ1	1.5094
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	I-BET-762	73.3381
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	JQ1	22.6985
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	I-BET-762	158.54
SIDM00101	MESO\|mesothelioma	p.W96* (No)	GDSC	OTX015	231.55
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	JQ1	1.6252
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	I-BET-762	8.8534
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	JQ1	8.733
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	I-BET-762	13.906
SIDM00257	NB\|neuroblastoma	p.A56S (No)	GDSC	OTX015	5.8639
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	JQ1	0.2808
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	31.1718
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	JQ1	8.2887
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	28.707
SIDM00517	UNCLASSIFIED\|head_and_neck	p.K435Q (No)	GDSC	OTX015	11.146
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.P299S (No)	GDSC	OTX015	1.163
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.A172V (No)	GDSC	OTX015	33.596
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.N37K (No)	GDSC	OTX015	33.596
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	JQ1	2.062
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	I-BET-762	76.4984
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	JQ1	12.3123
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	I-BET-762	42.213
SIDM00534	COREAD\|large_intestine	p.V26G (No)	GDSC	OTX015	33.596
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.4512
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	79.6804
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	32.6888
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	160.11
SIDM00680	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	32.631
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	JQ1	1.4146
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	I-BET-762	160.6765
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	JQ1	11.6441
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	I-BET-762	50.117
SIDM00336	SKCM\|melanoma	p.K435Q (No)	GDSC	OTX015	38.668
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	0.3787
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	3.8672
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	5.544
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	5.7033
SIDM00487	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	3.2362
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	0.3787
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	3.8672
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	JQ1	5.544
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	I-BET-762	5.7033
SIDM00487	COREAD\|large_intestine	p.E25fs*51 (No)	GDSC	OTX015	3.2362
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	75.1902
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	60.9888
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	JQ1	25.4093
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	I-BET-762	36.351
SIDM00282	COREAD\|large_intestine	p.P24fs*24 (No)	GDSC	OTX015	20.069
SIDM01041	ESCA\|oesophagus	p.T250P (Yes)	GDSC	I-BET-762	187.3981
SIDM01041	ESCA\|oesophagus	p.T250P (Yes)	GDSC	JQ1	16.7627
SIDM01041	ESCA\|oesophagus	p.T250P (Yes)	GDSC	I-BET-762	19.518
SIDM01041	ESCA\|oesophagus	p.T250P (Yes)	GDSC	OTX015	4.1478
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	JQ1	0.1772
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	I-BET-762	25.8739
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	JQ1	33.1636
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	I-BET-762	3.5792
SIDM00136	COREAD\|large_intestine	p.P149A (No)	GDSC	OTX015	1.2126
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	JQ1	0.7477
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	I-BET-762	65.0716
SIDM01082	HNSC\|head_and_neck	p.K435Q (No)	GDSC	JQ1	4.4795
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.I132fs*111 (No)	GDSC	OTX015	13.116
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	JQ1	0.3557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	I-BET-762	2.6358
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	JQ1	0.3064
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	I-BET-762	3.7152
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.A172V (No)	GDSC	OTX015	1.2985
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	0.5633
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	69.2874
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	8.5171
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	I-BET-762	51.757
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	OTX015	9.2643
SIDM00628	BRCA\|breast	p.A172V (No)	GDSC	JQ1	37.01
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P355L (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P355S (No)	GDSC	JQ1	16.7562
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	JQ1	0.7323
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	I-BET-762	286.8657
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	JQ1	4.1512
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	I-BET-762	298.43
SIDM00120	PRAD\|prostate	p.A10T (No)	GDSC	OTX015	55.349
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	JQ1	24.6189
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	I-BET-762	263.6372
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	JQ1	12.8474
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	I-BET-762	105.86
SIDM00114	MESO\|mesothelioma	p.R631K (No)	GDSC	OTX015	77.226
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.V174M (No)	GDSC	JQ1	0.9524
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.V174M (No)	GDSC	I-BET-762	52.969
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	JQ1	9.5591
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	I-BET-762	260.247
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	JQ1	16.3669
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	I-BET-762	5.9033
SIDM00541	COREAD\|large_intestine	p.E144V (No)	GDSC	OTX015	2.4086
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	JQ1	0.5954
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	I-BET-762	3.5792
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	JQ1	10.7262
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	I-BET-762	11.765
SIDM00738	LUAD\|lung_NSCLC_adenocarcinoma	p.P23H (No)	GDSC	OTX015	2.6699
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.V174M (No)	GDSC	JQ1	4.9806
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	JQ1	0.2855
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	I-BET-762	1.5369
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	JQ1	8.8691
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	I-BET-762	7.1915
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.A138V (No)	GDSC	OTX015	2.3039
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (Yes)	GDSC	JQ1	0.1659
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (Yes)	GDSC	I-BET-762	0.6404
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (Yes)	GDSC	JQ1	0.1489
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (Yes)	GDSC	I-BET-762	3.2944
SIDM00364	ALL\|lymphoblastic_leukemia	p.T250P (Yes)	GDSC	OTX015	0.7053
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	JQ1	2.4537
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	I-BET-762	86.2642
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	JQ1	15.1263
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	I-BET-762	107.62
SIDM00080	SKCM\|melanoma	p.Q662* (No)	GDSC	OTX015	41.066
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	JQ1	0.3574
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	I-BET-762	9.9296
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	I-BET-762	29.802
SIDM00465	OV\|ovary	p.E689* (No)	GDSC	OTX015	15.549
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	4.2039
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	15.805
SIDM00285	NB\|neuroblastoma	p.K435Q (No)	GDSC	OTX015	16.891
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	JQ1	6.9238
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	I-BET-762	46.4669
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	JQ1	7.7194
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	I-BET-762	227.3
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.K591R (No)	GDSC	OTX015	203.5
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	3.5773
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	174.9391
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	JQ1	13.1046
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	I-BET-762	37.853
SIDM01169	OV\|ovary	p.P24fs*24 (No)	GDSC	OTX015	4.4771
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	JQ1	3.5773
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	I-BET-762	174.9391
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	JQ1	13.1046
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	I-BET-762	37.853
SIDM01169	OV\|ovary	p.E25fs*51 (No)	GDSC	OTX015	4.4771
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	4.4809
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	I-BET-762	61.1974
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	34.4732
SIDM00892	BRCA\|breast	p.P188A (No)	GDSC	JQ1	20.534
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	JQ1	0.3787
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	I-BET-762	58.6481
SIDM01246	NB\|neuroblastoma	p.K435Q (No)	GDSC	JQ1	4.1927
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	2.7845
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	I-BET-762	71.8758
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	8.9974
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	I-BET-762	17.667
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	OTX015	9.1906
SIDM00875	UNCLASSIFIED\|breast	p.V174M (No)	GDSC	JQ1	4.1871
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	0.4262
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	195.2428
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	JQ1	10.3097
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	I-BET-762	39.801
SIDM00333	UCEC\|endometrium	p.E25fs*51 (No)	GDSC	OTX015	22.454
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	I-BET-762	95.874
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	I-BET-762	11.965
SIDM00118	COREAD\|large_intestine	p.N92K (No)	GDSC	OTX015	3.7042
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	0.641
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	201.9926
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	JQ1	9.0853
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	I-BET-762	19.258
SIDM00596	UCEC\|endometrium	p.P24fs*24 (No)	GDSC	OTX015	5.1627

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTTT

Degron related mutations and impact score

Drug responses associated with BRD3 mutations

All proteins holding degron of ADTTT