DegronMD

Uniprot ID: O00592

Source protein: Podocalyxin

Source gene: PODXL

Class: DEG_SPOP_SBC_1

Location: 129:133

E3 ligase: SPOP

DEGRON score: 0.8638

ASA_SCORE: 90.46

COIL: 0.881

CONS_SCORE: 0.3404

DSS_SCORE: 0.5958

HELIX: 0.0358

FCONS_SCORE: 0.9601

RIG_SCORE: 0.6969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E121K	TCGA-EE-A3AB	SKCM	TCGA	ADTTT	DEG_SPOP_SBC_1	0.1111
p.I120N	TCGA-VQ-A8E3	STAD	TCGA	ADTTT	DEG_SPOP_SBC_1	0.0833
p.T128A	DO48368	BLCA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.75
p.A141D	DO229028	LICA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1111
p.K129N	DO52304	LIHC	ICGC	ADTTT	DEG_SPOP_SBC_1	0.6918
p.E123K	DO222670	MELA	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1667
p.E123K	DO38057	SKCM	ICGC	ADTTT	DEG_SPOP_SBC_1	0.1667
p.I122N	DO51759	STAD	ICGC	ADTTT	DEG_SPOP_SBC_1	0.5833
p.I120T	SIDM00607	Glioblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.I120T	SIDM00083	Glioblastoma	GDSC	ADTTT	DEG_SPOP_SBC_1	0.0833
p.I120T	ACH-000622	Brain Cancer	CCLE	ADTTT	DEG_SPOP_SBC_1	0.0833
p.I120T	KNS-42	central_nervous_system	COSMIC	ADTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	129:133	ADTTT	SPOP	0.8638	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	292:296	ADTTT	SPOP	0.9991	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	283:287	ADTTT	SPOP	0.9945	More...
P39060	Collagen alpha-1	DEG_SPOP_SBC_1	58:62	ADTTT	SPOP	0.8165	More...
Q15059	Bromodomain-containing protein 3	DEG_SPOP_SBC_1	246:250	ADTTT	SPOP	0.9976	More...
Q58F21	Bromodomain testis-specific protein	DEG_SPOP_SBC_1	215:219	ADTTT	SPOP	0.9952	More...
Q6ZVD8	PH domain leucine-rich repeat-containing protein phosphatase 2	DEG_SPOP_SBC_1	38:42	ADTTT	SPOP	0.9983	More...
Q9H9B1	Histone-lysine N-methyltransferase EHMT1	DEG_SPOP_SBC_1	667:671	ADTTT	SPOP	0.9939	More...
Q8N9M1	Uncharacterized protein C19orf47	DEG_SPOP_SBC_1	251:255	ADTTT	SPOP	0.9047	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons